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Fitting plasma TAC
Mathematical functions can be fitted to measured plasma or blood TAC to make
the curve smoother and/or to allow extrapolation of the curve.
How?
The programs listed below can be run in MS Windows or Solaris/Linux command
prompt window.
Exponential functions
fit_exp,
extrapol.
Rational functions
fit_ratf
Feng et al. function
Model suggested by Feng et al. (1993):
fit_feng
Function for short infusion protocols used by Oakes et al. (1999):
fit_sinf
Sigmoidal functions
fit_gvar,
fit_hiad,
fit_sigm.
Computing curves from function parameters
fit2dat
Format of fitted datafiles.
References:
Feng D, Huang S-C, Wang X. Models for computer simulation studies of input
functions for tracer kinetic modeling with positron emission tomography.
Int J Biomed Comput. 1993; 32: 95-110.
Oakes ND, Kjellstedt A, Forsberg G-B, Clementz T, Camejo G, Furler SM,
Kraegen EW, Ölwegård-Halvarsson M, Jenkins AB, Ljung B.
Development and initial evaluation of a novel method for
assessing tissue-specific plasma free fatty acid utilization
in vivo using (R)-2-bromopalmitate tracer.
J Lipid Res. 1999; 40: 1155-1169.
