Enzyme inhibition can be determined with PET in similar manner as receptor occupancy.
Enzyme activity parameters are estimated from two PET studies, in baseline, and during medication. Enzyme inhibition (EI) can then be calculated from equation
Useful parameters for calculation of enzyme inhibition are k3 and λk3.
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Updated at: 2015-08-03
Created at: 2011-11-21
Written by: Vesa Oikonen