PET in breast cancer

Whole-body PET scanners are not optimal for the evaluation of primary breast cancer, but have been used for the staging of metastatic disease beyond the breast. High-resolution dedicated breast PET scanners offer 1.5-2.0 mm spatial resolution, allowing for reliable detection of even small lesions (García Hernández et al., 2016; O’Connor et al., 2017).

[18F]FDG is the most used PET tracer for breast cancer imaging, but other tracers could be used as well (Wahl et al., 1993; Fowler, 2014; Lebron et al., 2015; Dalm et al., 2016). [18F]FDG may be useful in staging and detection of metastases in male breast cancer patients, as well (Ulaner et al., 2019). Dynamic [18F]FDG PET can provide both K1 and Ki, which predict disease-free survival better than SUV from static imaging (Dunnwald et al., 2011).

Perfusion in breast tumours has been studied using radiowater PET, and the initial uptake rate of other tracers, such as [18F]FDG (Eby et al., 2008; Specht et al., 2010). [18F]fluoride PET can be used to estimate perfusion and fluoride uptake in bone metastases (Doot et al., 2010), but not in primary breast cancer (Sarikaya et al., 2018).

Amino acid tracer [18F]fluciclovine is used for the detection of recurrent prostate cancer, but it has also shown promise in imaging of breast cancer (Ulaner et al., 2018). L-[11C]methionine is also useful for detecting breast cancer (Leskinen-Kallio et al., 1991a; Huovinen et al., 1993).

Gastrin-releasing peptide receptors are overexpressed in breast cancer, and specific PET tracers have been used to detect the tumours.

Integrin αvβ3 in vascular endothelial cells is overexpressed in breast cancer, and could be used as a target in detecting breast cancer (Chen et al., 2018).

Mutations, amplifications, and fusions of FGFR genes have been observed in tumours. In breast cancer the genetic alterations in FGFR1 and FGFR2 are found especially in treatment resistant tumours, offering a target for new therapies. For instance, an FGFR inhibitor dovitinib dilactic acid decreased tumour growth and [18F]FDG uptake in mice model of human breast cancer (Kähkönen et al., 2019).


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References:

Bombardieri E, Bonadonna G, Gianni L (eds.): Breast Cancer - Nuclear Medicine in Diagnosis and Therapeutic Options. Springer, 2008. ISBN 978-3-540-36780-2. doi: 10.1007/978-3-540-36781-9.

Piccart MJ, Wood WC, Hung C-M, Solin LJ, Cardoso F (eds.): Breast Cancer and Molecular Medicine. Springer, 2006. ISBN 978-3-540-28265-5. doi: 10.1007/978-3-540-28266-2.



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Updated at: 2019-04-24
Created at: 2018-01-09
Written by: Vesa Oikonen