Input data for simulation
Error-free input curves are needed to create simulated tissue data with compartmental models. What exactly is needed depends on the tracer and model, but usually the input data consists of total radioactivity concentration in arterial blood and the parent tracer concentration in arterial plasma.
As a rule, the steps in making input data are:
- Collect a representative set of measured blood and plasma time-activity curves (TACs), and parent tracer fractions in plasma.
- Calculate average blood and plasma TAC, and average curve of parent tracer fractions in plasma.
- Fit appropriate function to average blood and plasma curves and to average parent tracer fractions, to remove noise and enable interpolation and extrapolation.
- Compute curves from the function parameters with frequent sample times.
Ready-made input TACs for simulations:
- [15O]H2O bolus studies
- [18F]FDG bolus studies: fasting (Långsjö et al., 2005) and euglycemic clamp (Lautamäki et al., 2005)
- [11C]carfentanil bolus studies
- [11C]flumazenil bolus studies
Created at: 2010-09-20
Updated at: 2017-06-01
Written by: Vesa Oikonen