Arginase and PET
Arginase is a metalloenzyme that catalyses the hydrolysis of L-arginine to L-ornithine and urea. Cytosolic arginase type I (Arg1) is expressed predominantly in the liver. Arginase type II (Arg2) is expressed in mitochondria throughout extrahepatic tissues. Arginase competes for L-arginine with nitric oxide synthases (NOSs) which produce vasodilator nitric oxide (NO).
[18F]FBMARS is a arginase inhibitor that has shown selective arginase-mediated tumour uptake in a mouse model (Clemente et al., 2021).
Caldwell RW, Rodriguez PC, Toque HA, Narayanan SP, Caldwell RB. Arginase: a multifaceted enzyme important in health and disease. Physiol Rev. 2018; 98(2): 641–665. doi: 10.1152/physrev.00037.2016.
Dzik JM. Evolutionary roots of arginase expression and regulation. Front Immunol. 2014; 5: 544. doi: 10.3389/fimmu.2014.00544.
Updated at: 2023-01-20
Created at: 2021-11-29
Written by: Vesa Oikonen