arlkup - tpcclib 0.7.0 © 2018 by Turku PET Centre

Calculation of perfusion look-up table from [O-15]H2O blood curve
for usage with PET in vivo autoradiographic (ARG) method.
 
Usage: arlkup [options] BTAC p fMax start dur lkupfile
 
Options:
 -static=<y|N>
     The look-up table integral can be corrected for physical decay as
     single frame when static PET scan was performed (y), or dynamically
     (N, the default).
 -nr=<value>
     Set the size of look-up table; 5000 by default.
 -h, --help
     Display usage information on standard output and exit.
 -v, --version
     Display version and compile information on standard output and exit.
 -d[n], --debug[=n], --verbose[=n]
     Set the level (n) of debugging messages and listings.
 -q, --quiet
     Suppress displaying normal results on standard output.
 -s, --silent
     Suppress displaying anything except errors.
 
Blood TAC (BTAC) must be calibrated and corrected for decay. Sample times
must be in sec unless correctly specified inside the BTAC file.
Concentrations must be in the same units as the units of PET tissue data.
Partition coefficient of water (p) must be given in units mL/mL,
and maximal perfusion (fMax) in units mL/(min*100mL).
Integration start time and duration is given in sec.
 
Look-up table will contain 2 columns: TTAC integral [sec*kBq/mL] and
blood flow [mL/(min*100mL)].
 
Example:
     arlkup -nr=2000 s1456_blo.fit 0.8 50 0 120 s1456.lkup
 
References:
1. Raichle ME. Quantitative in vivo autoradiography with positron emission
   tomography. Brain Res Rev. 1979;1:47-68.
2. Herscovitch P, Markham J, Raichle ME. Brain blood flow measured with
   intravenous H215O. I. Theory and error analysis.
   J Nucl Med. 1983;24:782-789.
3. Raichle ME, Martin WRW, Herscovitch P, Mintun MA, Markham J. Brain blood
   flow measured with intravenous H215O. II. Implementation and validation.
   J Nucl Med. 1983;24:790-798.
4. Ruotsalainen U, Raitakari M, Nuutila P, Oikonen V, Sipila H, Teras M,
   Knuuti J, Bloomfield PM, Iida H. Quantitative blood flow measurement of
   skeletal muscle using oxygen-15-water and PET. 
   J Nucl Med. 1997; 38:314-319.
 
See also: fitdelay, imginteg, imglkup, taclkup, tacunit, imgbfbp, imgflow
 
Keywords: perfusion, blood flow, radiowater, autoradiography, ARG, look-up table