eabaort 2.0.2 © 2005-2013 by Turku PET Centre

Extracts arterial input curve from human abdominal region of a dynamic [O-15]H2O PET image by finding the aorta, and corrects it with recovery coefficient based on method by Germano et al. (1). The current method does also account for effect of background radioactivity on recovery coefficient (3). Supported file formats are ECAT 6.3, ECAT 7, NIfTI-1, and Analyze 7.5. In case of NIfTI and Analyze image input, you need to add the frame information to the blood data separately. This can be done with program dftframe. NOTICE: all image planes should contain a clear view of the abdominal aorta that has not yet split into two vessels, and no other high spots; crop the image before using this program. NOTICE: It is recommended that either the full width half maximum (FWHM) value or individually measured aorta diameter is specified as command-line option, because both cannot be reliably estimated from a noisy image. NOTICE: It is also recommended that the full width half maximum (FWHM) value is determined for each scanner and reconstruction method. Usage: eabaort [Options] <PET image> <Blood file> Options: -FWHM=<value|fit> Enter a fixed value for FWHM (mm); fitted by default. Results will not be reliable unless either FWHM or vessel diameter is measured and fixed. -diameter=<value> Enter a fixed value for inner vessel diameter (mm); fitted by default. Results will not be reliable unless either FWHM or vessel diameter is measured and fixed. -plane=<Mean|Median|Best>. Model is fitted separately to all image planes, and by default the mean FWHM and vessel diameter is used to estimate an average blood TAC using all image planes. With this option the median can be used instead of the mean, or blood TAC can be estimated only from the plane that provides the highest fitted peak. -model=<germano|gaussian> Select the PVE simulation method; Gaussian smoothing by default. -pixelsize=<value> Set image pixel size (mm) if image header does not valid pixel size. -fitsize=<value> Length (mm) of the fit square side. By default, 30x30mm square surrounding the peak pixel value is used in the fit. -sum=<filename> Save sum image subvolume which is used to fit vessel position. -sumfit=<filename> Save fitted sum image subvolume. -bkg=<filename> Model estimated background curve. -peak=<filename> Model estimated peak TAC (not corrected for recovery error). -subvol=<filename> Subrange of the original dynamic image used in fit; for testing. Example 1: FWHM is measured, vessel diameter is estimated from image: eabaort -FWHM=6.3 -diameter=best s9876dy1.v s9876ab.dat Example 2: vessel diameter is measured, FWHM is estimated from image: eabaort -FWHM=fit -diameter=19.2 s9876dy1.v s9876ab.dat References: 1. Germano G, Chen BC, Huang S-C, Gambhir SS, Hoffman EJ, Phelps ME. Use of abdominal aorta for arterial input function determination in hepatic and renal PET studies. J Nucl Med 1992;33:613-620. 2. Scremin OU, Cuevas-Trisan RL, Scremin E, Brown CV, Mandelkern MA. Functional electrical stimulation effect on skeletal muscle blood flow measured with H215O positron emission tomography. Arch Phys Med Rehabil 1998;79:641-646. 3. Brix G, Belleman ME, Hauser H, Doll J. Recovery-koeffizienten zur quantifierung der arteriellen inputfunktion aus dynamischen PET- messungen: experimentelle und theoretische bestimmung. Nuklearmedizin 2002;41:184-190. See also: fit_h2o, imgflow, fitdelay, fit_winp, imgbox, simiart Keywords: input, image, modelling, abdominal aorta This program comes with ABSOLUTELY NO WARRANTY. This is free software, and you are welcome to redistribute it under GNU General Public License.

GNU GPL

Last updated 2013-06-26 11:08:03