# fith2met 0.2.0 © 2009,2012 Turku PET Centre

Fits the Hill type function to plasma fraction curves of parent tracer and
two metabolites. Functions fitted are:
Parent (unchanged) fraction:
f(x) = 1 - (A*x^B)/(C+x^B)
Metabolite 1 fraction:
f(x) = (f1*A*x^B)/(C+x^B)
Metabolite 2 fraction:
f(x) = ((1-f1)*A*x^B)/(C+x^B)
, where 0<A<=1 , B>0 , C>0
Usage: fith2met [Options] <Fraction file> [Fit file]
General options:
-nd Some fractions are known to exceed 1, not divided by 100.
-delay[=<time>]
Fit also delay time, or, set delay time (0 by default).
-h or --help
Print this message and exit.
--build or --version
Print software build information and exit.
--silent
Program works silently, printing only error and warning messages.
--verbose
Program prints more information about what it is doing.
Options to set weights:
-W1 All weights are set to 1.0; by default, sample times are used to
calculate weights unless weights are supplied in fraction file.
-WP=<weight>, -WM1=<weight>, -WM2=<weight>
Put additional or less weight to parent and/or metabolite fractions.
Fraction datafile must contain 3-4 columns, that is, sample times and
fractions of parent tracer and at least metabolite 1.
Weights can be specified as specified in DFT format (3);
any additional columns are ignored.
Lines that start with a '#' are not read from the datafile.
Program writes the fit start and end times, nr of points, WSS,
and parameters of the fitted function to the result (fit) file (4).
References:
1. Fitting the fractions of parent tracer in plasma.

http://www.turkupetcentre.net/analysis/doc/fraction_fit.html
2. Wu S, Ogden RT, Mann JJ, Parsey RV. Optimal metabolite curve fitting for
kinetic modeling of 11C-WAY-100635. J Nucl Med 2007;48:926-931.
3. DFT format.

http://www.turkupetcentre.net/analysis/doc/format_dft.html
4. FIT format.

http://www.turkupetcentre.net/analysis/doc/format_fit.html
See also:

fit2dat,

metabcor,

fit_ppf,

avgfract,

tac2svg
Keywords: input, plasma, modelling, simulation, metabolite correction
This program comes with ABSOLUTELY NO WARRANTY. This is free software, and
you are welcome to redistribute it under GNU General Public License.