heartcor - tpcclib 0.7.0 © 2018 by Turku PET Centre

Corrects regional myocardium and blood time-activity curves (TACs)
measured with PET for recovery and spillover fractions, and contribution
of blood activity in vascular space (10%) (Henze et al., 1983).
This method works properly, if regions-of-interest (ROIs) are drawn
in the middle of cavity and muscle, excluding the border areas.
Method is valid when cavity radius >> wall thickness and FWHM/2.36.
 
Usage: heartcor tacfile cav_id myo_id diameter thickness FWHM outputfile
 
Tacfile must contain at least the TACs of myocardial cavity and entire
myocardial muscle (or representative region of it). The names or numbers
of these TACs must be given as next command-line parameters.
Corrections based on these TACs are applied to any additional TACs in tacfile.
 
The diameter of cavity, myocardial wall thickness, and PET image resolution
must be given in millimeters.
 
Options:
 -Vb=<Vascular volume fraction>
     Set vascular volume fraction (0-0.9) in myocardial tissue;
     by default Vb=0.10
 -sim[ulate]
     Recovery and spillover errors are simulated and added to initially
     non-affected data, originating from compartmental model simulations;
     enter blood and muscle tissue TACs instead of cavity and myocardial
     region TACs, respectively.
 -h, --help
     Display usage information on standard output and exit.
 -v, --version
     Display version and compile information on standard output and exit.
 -d[n], --debug[=n], --verbose[=n]
     Set the level (n) of debugging messages and listings.
 -q, --quiet
     Suppress displaying normal results on standard output.
 -s, --silent
     Suppress displaying anything except errors.
 
Example 1: correction of regional PET data
     heartcor s6368dy.tac lv myo 52 10 10 s6368dy_cor.tac
 
Example 2: simulation of recovery and spillover effects, assuming Vb=8%%
     heartcor -simulate original.tac 1 2 40 10 8 simulated.tac
Example 3: calculate FMM, FMB, FBM, and FBB, without doing anything else
     heartcor none 1 2 40 10 8 none
 
Reference:
1. Henze E, Huang S-C, Ratib O, Hoffman E, Phelps ME, Schelbert HR.
   Measurements of regional tissue and blood-pool radiotracer
   concentrations from serial tomographic images of the heart.
   J Nucl Med. 1983;24:987-996.
 
See also: fitmbf, patlak, logan, simimyoc, taccalc, dftcbv
 
Keywords: TAC, myocardium, cavity, spill-over, recovery, simulation