## p2t_3c - tpcclib 0.7.4 © 2019 by Turku PET Centre

```Deprecated, use sim_3tcm instead.

Simulation of PET tissue time-radioactivity concentration curve (TAC)
from arterial plasma (Ca) TAC based on three-tissue compartmental model,
where the compartments are in series (default):
____    K1   ____    k3   ____    k5   ____
| Ca | ----> | C1 | ----> | C2 | ----> | C3 |
|____| <---- |____| <---- |____| <---- |____|
k2           k4           k6

dC1(t)/dt = K1*Ca(T) - (k2+k3)*C1(T) + k4*C2(T)
dC2(t)/dt = k3*C1(T) - (k4+k5)*C2(T) + k6*C3(T)
dC3(t)/dt = k5*C2(T) - k6*C3(T)
Ct(T) = C1(T) + C2(T) + C3(T)

, or, optionally, three-tissue compartmental model, where the 2nd and 3rd
tissue compartments are parallel, often used to represent specific and
non-specific binding:

____    K1   ____    k3   ____
| Ca | ----> | C1 | ----> | C2 |
|____| <---- |____| <---- |____|
k2           k4
| ^
k5 | | k6
v |
____
| C3 |
|____|

dC1(t)/dt = K1*Ca(T) - (k2+k3+k5)*C1(T) + k4*C2(T) + k6*C3(T)
dC2(t)/dt = k3*C1(T) - k4*C2(T)
dC3(t)/dt = k5*C1(T) - k6*C3(T)
Ct(T) = C1(T) + C2(T) + C3(T)

Usage: p2t_3c [options] plasmafile K1 k2 k3 k4 k5 k6 simfile

Options:
-paral[lel]
Model with parallel compartments C2 and C3 is applied.
-ser[ies]
Model with compartments C1, C2, and C3 in series is applied (default).
-sub | -nosub
TACs of sub-compartments (C1, C2 and C3) are written (-sub, default)
or not written (-nosub) into the simfile.
-h, --help
Display usage information on standard output and exit.
-v, --version
Display version and compile information on standard output and exit.
-d[n], --debug[=n], --verbose[=n]
Set the level (n) of debugging messages and listings.
-q, --quiet
Suppress displaying normal results on standard output.
-s, --silent
Suppress displaying anything except errors.

Example:
p2t_3c -nosub plasma.dat 0.3 0.2 0.1 0.2 0 0 sim.dat