p2t_3c - tpcclib 0.7.4 © 2019 by Turku PET Centre

Deprecated, use sim_3tcm instead.
 
Simulation of PET tissue time-radioactivity concentration curve (TAC)
from arterial plasma (Ca) TAC based on three-tissue compartmental model,
where the compartments are in series (default): 
  ____    K1   ____    k3   ____    k5   ____   
 | Ca | ----> | C1 | ----> | C2 | ----> | C3 |  
 |____| <---- |____| <---- |____| <---- |____|  
          k2           k4           k6          
 
  dC1(t)/dt = K1*Ca(T) - (k2+k3)*C1(T) + k4*C2(T) 
  dC2(t)/dt = k3*C1(T) - (k4+k5)*C2(T) + k6*C3(T) 
  dC3(t)/dt = k5*C2(T) - k6*C3(T)                 
  Ct(T) = C1(T) + C2(T) + C3(T)                 
 
, or, optionally, three-tissue compartmental model, where the 2nd and 3rd
tissue compartments are parallel, often used to represent specific and
non-specific binding:
 
  ____    K1   ____    k3   ____   
 | Ca | ----> | C1 | ----> | C2 |  
 |____| <---- |____| <---- |____|  
          k2           k4          
                | ^                
             k5 | | k6             
                v |                
               ____                
              | C3 |               
              |____|               
 
  dC1(t)/dt = K1*Ca(T) - (k2+k3+k5)*C1(T) + k4*C2(T) + k6*C3(T) 
  dC2(t)/dt = k3*C1(T) - k4*C2(T)  
  dC3(t)/dt = k5*C1(T) - k6*C3(T)  
  Ct(T) = C1(T) + C2(T) + C3(T)    
 
Usage: p2t_3c [options] plasmafile K1 k2 k3 k4 k5 k6 simfile
 
Options:
 -paral[lel]
     Model with parallel compartments C2 and C3 is applied.
 -ser[ies]
     Model with compartments C1, C2, and C3 in series is applied (default).
 -sub | -nosub
     TACs of sub-compartments (C1, C2 and C3) are written (-sub, default)
     or not written (-nosub) into the simfile.
 -h, --help
     Display usage information on standard output and exit.
 -v, --version
     Display version and compile information on standard output and exit.
 -d[n], --debug[=n], --verbose[=n]
     Set the level (n) of debugging messages and listings.
 -q, --quiet
     Suppress displaying normal results on standard output.
 -s, --silent
     Suppress displaying anything except errors.
 
Example:
     p2t_3c -nosub plasma.dat 0.3 0.2 0.1 0.2 0 0 sim.dat
 
See also: sim_3tcm, p2t_v3c, p2t_di, tacadd, tacren, simframe, dft2img
 
Keywords: TAC, simulation, modelling, compartmental model