p2t_fd 1.5.1 © 1995-2005 by Turku PET Centre

Simulates the regional brain PET TAC in a dynamic [F-18]FDOPA bolus study with specified parameters of the Kuwabara's compartmental model [1,2]. Parameters for the program: 1) Plasma FDOPA TAC file 2) Plasma OMFD TAC file 3) Blood TAC file 4) K1 5) Ve(=K1/k2) 6) k3 7) kLoss 8) Simulated tissue TAC file Options (with default values): -q=1.5 ; K1m/K1d -k5=0 -Vb=3.5 ; Blood volume fraction (%); Arterial and venous blood are assumed to be similar (f>>K1) Simulated TACs are written in output file in columns of 1) Time 2) Total tissue radioactivity concentration 3) FDOPA 4) Nondiffusible and diffusible metabolites (FDA, F-3-MT, FDOPAC, FHVA) 5) OMFD 6) Vascular contribution to tissue TAC References: 1. Kuwabara H et al. Human striatal L-DOPA decarboxylase activity estimated in vivo using 6-[18F]fluoro-DOPA and positron emission tomography: error analysis and application to normal subjects. J Cereb Blood Flow Metab 1993;13:43-56. 2. Kuwabara H et al. Regional striatal DOPA transport and decarboxylase activity in Parkinson's disease. J Nucl Med 1995;36:1226-1231. See also: fitfdopa, dftadd, fr4sim, dftren, dft2img

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Last updated 2005-03-08 20:02:15