sim_av - tpcclib 0.7.8 © 2022 by Turku PET Centre

Simulation of venous BTAC (Cv) from arterial BTAC (Ca), based on
three-tissue compartmental model:
 
  ____    K1   ____    k3   ____    k5   ____     
 | Ca | ----> | C1 | ----> | C2 | ----> | C3 |    
 |____| <---- |____| <---- |____| <---- |____|    
          k2           k4           k6            
 
  dC1(t)/dt = K1*Ca(T) - (k2+k3)*C1(T) + k4*C2(T) 
  dC2(t)/dt = k3*C1(T) - (k4+k5)*C2(T) + k6*C3(T) 
  dC3(t)/dt = k5*C2(T) - k6*C3(T)                 
  Ct(T) = C1(T) + C2(T) + C3(T)                   
  Cv(T) = Ca(T) - dCt(t)/dt / f 
 
Usage: sim_av [options] parfile [abtacfile simfile]
 
Options:
 -ttac=<Filename>
     Simulated tissue curve is written in specified file.
 -h, --help
     Display usage information on standard output and exit.
 -v, --version
     Display version and compile information on standard output and exit.
 -d[n], --debug[=n], --verbose[=n]
     Set the level (n) of debugging messages and listings.
 -q, --quiet
     Suppress displaying normal results on standard output.
 -s, --silent
     Suppress displaying anything except errors.
 
To create a template parameter file, do not enter names for input and
simulated TACs. Obligatory parameters are f, K1, K1/k2, k3, k3/k4.
Parameters k5 and k5/k6 are optional.
If parameter file does not contain units, then per min and per mL units
are assumed.
For accurate results, BTAC should have very short sampling intervals.
To reduce the model, k3 or k3/k4 can be set to 0, to apply one-tissue or
irreversible two-tissue model, respectively, or k5 or k5/k6 can be set to 0,
to apply two-tissue or irreversible three-tissue model, respectively.
 
See also: sim_3tcm, tacadd, taccalc, tac2svg, convexpf, fit_xexp
 
Keywords: input, simulation, modelling, compartmental model