sim_rtcm - tpcclib 0.7.4 © 2019 by Turku PET Centre

Simulation of PET tissue time-radioactivity concentration curves (TAC) from
reference tissue TAC based on a selected reference tissue input compartment
model.
Available reference tissue input models, and model parameters:
  FRTM; (Full) reference tissue model; R1, k2, k3, BP [1]
  SRTM: Simplified reference tissue model; R1, k2, BP [2]
  RRTM: Reduced reference tissue model; R1, k2, k3 (k4=0)
  TRTM: Transport-limited reference tissue model; R1, k2, k3 [3]
 
Usage: sim_rtcm [options] parfile [reffile simfile]
 
Options:
 -model=<FRTM|SRTM|RRTM|TRTM>
     Select the model used to simulate the TACs; by default the model is
     read from the parameter file.
 -sub | -nosub
     TACs of sub-compartments (Cf and Cb) are also written (-sub) into
     simfile, or not written (-nosub, default); effective only with FRTM.
 -h, --help
     Display usage information on standard output and exit.
 -v, --version
     Display version and compile information on standard output and exit.
 -d[n], --debug[=n], --verbose[=n]
     Set the level (n) of debugging messages and listings.
 -q, --quiet
     Suppress displaying normal results on standard output.
 -s, --silent
     Suppress displaying anything except errors.
 
To create a template parameter file, do not enter names for reference TAC
and simulated TACs, but give the model with option -model.
 
References:
1. Cunningham VJ, Hume SP, Price GR, Ahier RG, Cremer JE, Jones AKP.
   Compartmental analysis of diprenorphine binding to opiate receptors
   in the rat in vivo and its comparison with equilibrium data in vitro.
   J Cereb Blood Flow Metab 1991;11:1-9.
2. Lammertsma AA, Hume SP. Simplified reference tissue model for PET
   receptor studies. NeuroImage 1996;4:153-158.
3. Herholz K, Lercher M, Wienhard K, Bauer B, Lenz O, Heiss W-D.
   PET measurement of cerebral acetylcholine esterase activity without
   blood sampling. Eur J Nucl Med 2001;28:472-477.
 
See also: sim_3tcm, fit_frtm, fit_srtm, fit_rrtm, fit_trtm, tacadd, simframe
 
Keywords: TAC, simulation, reference tissue, reference input