b2plasma 1.7.4 © 2002-2009 by Turku PET Centre
Converts PET blood TACs to plasma TACs, based on tracer dependent
ratio of red blood cell (RBC) and plasma concentration curve.
Usage: b2plasma [Options] <Tracer> <Bloodfile> <HCr> <Plasmafile>
Options:
-Log
Log information is saved in output file.
-h or --help
Print this message and exit
--version or --build
Print software build information and exit
--silent
Program works silently, printing only error and warning messages
--verbose
Program prints lots of information about what it is doing.
The following tracers can be converted:
AH690
ratio is assumed to follow a population average curve.
AH691
ratio is assumed to follow a population average curve.
Carfentanil
ratio is assumed to follow a population average curve
(unpublished measurements from eight 70-min PET studies).
FBPA
ratio is assumed to rise from zero with slope 0.00888
(unpublished measurement from 10 subjects).
FDG
ratio is assumed to be 0.8 in the beginning and to rise with
slope 0.0012/min (Phelps ME et al. Ann Neurol 1979;6:371-388).
FDOPA
ratio is assumed to follow equation R(t)=(Rmax*t)/(Th+t),
where Rmax=1.446 and Th=83.56 (unpublished results).
Flu[mazenil]
ratio is assumed to follow an average curve based on two
subjects with assumed HCR=0.43.
FTHA
concentration in red blood cells is assumed to be zero.
MEAIB
ratio is assumed to rise from zero with slope 0.00398
(unpublished measurement from 7 subjects).
Metomidate or MTO
concentration is the same in RBC and plasma water.
ORM-B
ratio is assumed to follow a population average curve
(unpublished measurement from 6 subjects studied twice).
Palm[itate]
ratio is assumed to follow a population average curve
(unpublished measurement from 8 subjects).
PE2I
ratio is assumed to follow a population average curve
(unpublished measurements from ten 70-min PET studies).
PIB or 6OHBTA1
ratio is assumed to follow a population average curve,
currently based on 15 subjects.
PK11195
ratio is assumed to follow a curve based on one
subject with measured HCr.
Codes for tracers that have below mentioned properties:
norbc
concentration in red blood cells is assumed to be zero.
inwater
concentration is the same in RBC and plasma water.
Times must be in minutes in data files, or seconds, if appropriately
specified inside the file. File format specification in
http://www.turkupetcentre.net/analysis/doc/format_dft.html
The hematocrit (HCr, HCT) is normally between 0.40-0.51 in men and 0.36-0.47
in women. Note that HCr is lower in small vessels.
Example: estimate plasma curve from measured FDG blood TAC:
b2plasma FDG i3344ab.kbq 0.38 i3344ap.kbq
See also:
p2blood,
b2rbc,
bpr2cpr,
dftcalc,
dftcat
Keywords: input, modelling, simulation, blood, plasma, RBC, hematocrit
This program comes with ABSOLUTELY NO WARRANTY. This is free software, and
you are welcome to redistribute it under GNU General Public License.
