fit_srtm 3.1.0 © 1999-2013 by Turku PET Centre
Estimates R1 (=K1/K1'), k2 and BPnd (binding potential) using simplified
reference tissue compartment model, SRTM (1,2,3). Assumptions are that
K1/k2 is the same in all brain regions, and that a one-tissue compartment
model with plasma input could fit the tissue curves satisfactorily.
This program uses nonlinear regression in model fitting.
Parameters:
1) Tissue TAC file (in DFT, PMOD, or CSV format)
2) Name of reference region in tissue file, or name of file
containing reference tissue TAC
3) Fit time (in minutes from injection)
4) Result file (existing file is overwritten) (4)
Options:
-DVR
Instead of BPnd, program saves the DVR (=BPnd+1) values.
-lim=<filename>
Specify the constraints for model parameters;
This file with default values can be created by giving this
option as the only command-line argument to this program.
-SD[=<y|N>]
Standard deviations are calculated and saved in results (y), or
not calculated (n).
-CL[=<y|N>]
95% Confidence limits are calculated and saved in results (y), or
not calculated (n).
-fit=<Filename>
Fitted regional TACs are written in file.
-svg=<Filename>
Fitted and measured TACs are plotted in specified SVG file (5).
-h or --help
Print this message and exit.
--version or --build
Print software build information and exit.
--silent
Program works silently, printing only error and warning messages.
--verbose
Program prints more information about what it is doing.
If datafile contains weights, those are used in the fitting.
Values of R1, k2, and BPnd are written in the specified result file.
Fitted curves are written in DFT format, if filename is given.
Example 1: file a789.dft contains regions-of-interest and reference region,
with name 'cer all'. The whole time range is used in the fit.
fit_srtm a789.dft 'cer all' 999 a789.res
Example 2: Reference region TAC is in a separate file, a789ref.dft.
Standard deviations and confidence limits are also estimated.
fit_srtm -SD=y -CL=y a789.dft a789ref.dft 999 a789.res
References:
1. Cunningham VJ, Hume SP, Price GR, Ahier RG, Cremer JE, Jones AKP.
Compartmental analysis of diprenorphine binding to opiate receptors
in the rat in vivo and its comparison with equilibrium data in vitro.
J Cereb Blood Flow Metab 1991;11:1-9.
2. Lammertsma AA, Hume SP. Simplified reference tissue model for PET
receptor studies. Neuroimage 1996;4:153-158.
3. Oikonen V, Sederholm K. TPCMOD0002: Model equations for reference tissue
compartmental models.
http://www.turkupetcentre.net/reports/tpcmod0002.pdf
4. File format specification: Result file.
http://www.turkupetcentre.net/formats/format_res_1_0_0.pdf
5. Scalable Vector Graphics (SVG) 1.1 Specification.
http://www.w3.org/TR/SVG/
See also:
dftweigh,
rescoll,
logan,
regbfbp,
fit_frtm,
r2t_rtcm
Keywords: DFT, modelling, binding potential, BP, SRTM, reference input
This program comes with ABSOLUTELY NO WARRANTY. This is free software, and
you are welcome to redistribute it under GNU General Public License.
