fit_winp 0.3.3 © 2010,2012 by Turku PET Centre
Fit blood time-activity curve (TAC) from PET [O-15]H2O study
to a six (1) or four parameter (2) function, when radiowater is
given to patient as a short infusion.
Command-line arguments:
1) Plasma TAC filename
2) Filename for fitted function parameters (optional)
Plasma data (3) must contain two columns: sample times and (radioactivity)
concentrations which preferably are corrected for physical decay and
circulating metabolites. Extra columns are ignored.
Function parameters will be written in the parameter file (4); note that
these describe dispersion corrected curve, if dispersion time constants
are specified.
Command-line options:
-tau1=<Dispersion time constant (s)>
-tau2=<2nd dispersion time constant (s)>
Dispersion (5) is added to function, also to saved curve and plot
-func=<331|332>
Select the function to be fitted; 331 is the default
-MRL
Error is returned if MRL check is not passed
-fast or -safe
Speed up the fitting but increase the chance of failure, or
increase the reliability at the cost of computing time
-wf
Weight by sampling interval
-fit=<Filename>
Fitted TAC is written in DFT format
-dcfit=<Filename>
Fitted dispersion corrected (5) TAC is written in DFT format;
can only be used when dispersion time constant is set
-svg=<Filename>
Fitted and measured TACs are plotted in specified SVG file
-h or --help
Print this message and exit
--version or --build
Print software build information and exit
--silent
Program works silently, printing only error and warning messages
--verbose
Program prints more information about what it is doing
Options for constraining the fit:
-Ti=<infusion time (s)>
Duration of tracer infusion; 0, if short bolus
-Ta=<appearance time (s)>
Time when tracer concentration starts ascending.
References:
1. Oakes ND et al. J Lipid Res. 1999;40:1155-1169.
2. Kudomi N et al. Eur J Nucl Med Mol Imaging 2008;35:1899-1911.
3.
http://www.turkupetcentre.net/analysis/doc/format_dft.html
4.
http://www.turkupetcentre.net/analysis/doc/format_fit.html
5. Iida H et al. J Cereb Blood Flow Metab. 1986;6:536-545.
See also:
fit2dat,
fit_sinf,
fit_feng,
disp4dft,
dfttime,
fitdelay
Keywords: input, modelling, simulation, dispersion, radiowater
This program comes with ABSOLUTELY NO WARRANTY. This is free software, and
you are welcome to redistribute it under GNU General Public License.
