fitkloss 2.3.1 © 2002-2012 by Turku PET Centre
Non-linear fitting of two-tissue compartment model with kLoss rate
to plasma and tissue time-activity curves (TACs) to estimate Vb, K1-k3 and
kLOSS using iTGO.
____ K1 ____ k3 ____
| Ca | ----> | | ----> | |
|____| <---- | C1 | | C2 |
| | k2 |____| | |
| Cv | kLoss | |
|____| <----------------- |____|
By default the parameters are restricted to the following values:
Parameter Lower limit Upper limit
K1 1E-5 5.0
K1/k2 1E-5 10.0
k3 0 5.0
kLOSS/k3 0 0.5
Vb% 0 40
Parameters:
1) Plasma file
2) Blood file
3) Tissue TAC file (*.dft)
4) Result file
Options:
-Vb=<Vb%>
Vascular volume fraction; fitted by default
-f=<K1/F>
K1/F-ratio; by default flow is ignored (F>>K1)
-a=<fA%>
Arterial volume fraction; 30 by default
-E=<time>
Fit time (duration); to the end of data by default
-SD[=<y|N>]
Standard deviations are calculated and saved in results (y),
or not calculated (N, default).
Program runs a lot faster if SD and CL are not calculated.
-CL[=<y|N>]
95% Confidence limits are calculated and saved in results (y), or
not calculated (N, default).
-fit=<Filename>
Fitted regional TACs are written in DFT format
-svg=<Filename>
Fitted and measured TACs are plotted in specified SVG file
-h or --help
Print this message and exit
--version or --build
Print software build information and exit
--silent
Program works silently, printing only error and warning messages
--verbose
Program prints more information about what it is doing
Example:
fitkloss s919ap.dat s919ab.dat s919.dft 999 s919.res
If datafile contains weights, those are used in the fitting.
Model parameters are written in the specified result file.
See also:
dftweigh,
patlak,
p2t_loss,
fitk4,
fitk3,
dft2svg,
rescoll
Keywords: DFT, modelling, loss rate, enzyme activity
This program comes with ABSOLUTELY NO WARRANTY. This is free software, and
you are welcome to redistribute it under GNU General Public License.
