imgbfbp 0.6.6 © 2003-2010 by Turku PET Centre
Computation of parametric images of binding potential (BPnd) from
dynamic PET images in ECAT or Analyze format applying simplified reference
tissue model (SRTM) [1]. The model is solved using the basis function
approach [2], similar to the RPM program.
Parameters:
1) Dynamic image file (corrected for decay)
2) Reference region TAC file (times in minutes!)
3) Parametric BP image file
4) SIF file (optional)
Example:
imgbfbp ua2918dy1.v ua2918cer.dft ua2918bp.v
Options:
-R1=<filename>
Programs computes also an R1 image
-k2=<filename>
Programs computes also a k2 image
-min=<value (1/min)>
Set minimum value for theta3; it must be >= k2min/(1+BPmax)+lambda.
Default is 0.06 min-1. Lambda for F-18 is 0.0063 and for C-11 0.034.
-max=<value (1/min)>
Set maximum value for theta3; it must be <= k2max+lambda.
Default is 0.60 min-1.
-nr=<value>
Set number of basis functions; default is 100.
-bf=<filename>
Basis functions are written in specified image file.
-wss=<filename>
Weighted sum-of-squares are written in specified image file.
-err=<filename>
Pixels with their theta3 in its min or max value are written
in the specified imagefile with values 1 and 2, respectively,
others with value 0.
-thr=<threshold%>
Pixels with AUC less than (threshold/100 x ref AUC) are set to zero;
default is 0%
-DVR
Instead of BP, program saves the DVR (=BP+1) values.
-noneg
Pixels with negative BP values are set to zero.
-end=<Fit end time (min)>
Use data from 0 to end time; by default, model is fitted to all frames.
-h or --help
Print this message and exit.
--version or --build
Print software build information and exit.
--silent
Program works silently, printing only error and warning messages.
--verbose
Program prints more information about what it is doing.
Fit is always weighted, either based on the counts in SIF provided by
user, or if SIF is not provided, then weights are estimated based on
mean radioactivity concentration in the dynamic image, and estimated SIF
is written with default filename.
References:
1. Lammertsma AA, Hume SP. Simplified reference tissue model for PET
receptor studies. NeuroImage 1996;4:153-158.
2. Gunn RN, Lammertsma AA, Hume SP, Cunningham VJ. Parametric imaging of
ligand-receptor binding in PET using a simplified reference region
model. NeuroImage 1997;6:279-287.
See also:
imgdv,
ecatunit,
cti2sif,
dftweigh,
edecay,
ecat2tif,
regbfbp
Keywords: image, modelling, binding potential, basis function method
This program comes with ABSOLUTELY NO WARRANTY. This is free software, and
you are welcome to redistribute it under GNU General Public License.
