paucinf 1.4.2 © 2002-2009 Turku PET Centre

Estimates the half-life (t1/2) and elimination rate constant (kEL) of a PET tracer in plasma, and the AUC of plasma time-activity curve from 0 to infinite time. AUC can be used e.g. to estimate the total clearance of PET tracer after a single intravenous dose: Dose Cl = -------- T AUC 0-Inf The natural logarithm of tracer concentration is plotted against time from bolus infusion. The plot becomes linear in the end phase, as the tracer is eliminated according to the laws of first-order reaction kinetics. The slope of the linear part of the plot equals -kEL. Usage: paucinf <Plasmafile> [Result file] Options: -end=<sample time> Use data from 0 to given time in the line fit; by default search for the best line fit extends to the last sample -start=<sample time> Use data from given time to end in the line fit; by default, the search for the best line fit extends to the first sample -winnonlin Best line fit is searched using algorithm that gives similar results to WinNonlin with the same simple model -svg=<Filename> Plots of log transformed TACs and fitted lines are written in specified file in Scalable Vector Graphics (SVG) 1.1 format; specification in http://www.w3.org/TR/SVG/ -h or --help Print this message and exit --version or --build Print software build information and exit --silent Program works silently, printing only error and warning messages --verbose Program prints more information about what it is doing. Plasmafile must contain a time column, and one or more concentration columns separated by space(s) or tabulator(s). The result is printed on screen. See also: extrapol, interpol, fit_exp, fit2dat Keywords: input, modelling, pharmacokinetics, clearance, elimination rate This program comes with ABSOLUTELY NO WARRANTY. This is free software, and you are welcome to redistribute it under GNU General Public License.