fit_wcbf - tpcclib 0.8.2 © 2025 by Turku PET Centre

Non-linear fitting of the radiowater model with PVC to brain TTACs using BTAC
as the input function (Iida et al., 2000).
 
Usage: fit_wcbf [Options] btacfile ttacfile [parfile]
 
Options:
 -Va=<value>
     Arterial blood volume is constrained to given value (mL/mL).
 -dt=<value>
     Delay time (activity appearance time in tissue minus that in blood)
     in seconds. Dispersion in BTAC is corrected in relation to delay
     as tau=0.31*dt-0.30 (Iida et al., 1989), when tau>0.
 -pGM=<value>
     Partition coefficient of water in grey matter; by default 1.03 mL/mL.
 -pWM=<value>
     Partition coefficient of water in white matter; by default 0.86 mL/L.
 -fWM=<value> | fit
     Blood flow in white matter; by default 0.21 mL/(min*mL).
     Enter 'fit' to estimate fW as a free parameter.
 -w1 | -wf
     By default, weights in data file are used, if available.
     With these options all weights can be set to 1.0 (no weighting)
     or based on frame durations.
 -svg=<Filename>
     Fitted and measured TACs are plotted in specified SVG file.
 -fit=<Filename>
     Fitted TTACs are written in specified TAC file.
 -sim=<Filename>
     Fitted TTACs at BTAC sample times are saved in specified TAC file.
 -h, --help
     Display usage information on standard output and exit.
 -v, --version
     Display version and compile information on standard output and exit.
 -d[n], --debug[=n], --verbose[=n]
     Set the level (n) of debugging messages and listings.
 -q, --quiet
     Suppress displaying normal results on standard output.
 -s, --silent
     Suppress displaying anything except errors.
 
Sample times must be in seconds, unless units are specified in the file.
 
Reference:
1. Iida H et al., Quantitation of regional cerebral blood flow corrected
   for partial volume effect using O-15 water and PET: I. Theory, error
   analysis, and stereologic comparison.
   J Cereb Blood Flow Metab. 2000;20(8):1237-1251.
   https://doi.org/10.1097/00004647-200008000-00009
2. Iida et al., A determination of the regional brain/blood partition
   coefficient of water using dynamic positron emission tomography.
   J Cereb Blood Flow Metab. 1989;9(6):874-885.
   https://doi.org/10.1038/jcbfm.1989.121
 
See also: fit_h2o, bfmh2o, fitk2
 
Keywords: TAC, modelling, perfusion, brain, radiowater