b2t_mo2 1.2.0 © 2002-2008 by Turku PET Centre
Simulates regional skeletal muscle PET radioactivity concentration curves
in [O-15]O2 studies from decay corrected blood [O-15]O2 and [O-15]H2O
curves using the following compartmental model dedicated for skeletal
muscle (1-3):
Blood Muscle
_______________________________________
| K1 | |
| O ----------> O + O -Mb |
| 2 <---------- 2 2 |
| k2 |
| | | k3 |
| | V |
| K1 | |
| H O ----------> H O |
| 2 <---------- 2 |
| | K1/pH2O |
|______________|________________________|
Model definitions:
K1=Flow (mL/min/dL), OER=k3/(k2+k3),
Ki=Flow*OER (mL/min/dL),
Metabolic rate of oxygen MRO2=Ki*[O2]a (mmol/min/dL)
Command line arguments:
1) Blood O2 TAC file
2) Blood H2O TAC file
3) Flow, mL/(dL*min)
4) Oxygen extraction fraction OER (fraction)
5) Simulated tissue TAC file
General options:
-h or --help
Print this message and exit
--version or --build
Print software build information and exit
--silent
Program works silently, printing only error and warning messages
--verbose
Program prints lots of information about what it is doing
-sub and -nosub
With option -sub the TACs of all model compartments will be written in
output tissue file, but with -nosub (default) only total tissue TAC
will be saved
-voiname=<text>
Enter a name (1-6 chars without spaces) for the simulated TAC
Options to set model parameters:
-Vb=<Blood volume (%)>
Set the simulated blood volume; default is 3.5%
-Af=<Arterial proportion (%)>
Set the simulated arterial proportion of total blood volume;
default is 30%
-pH2O=<value>
Set the partition coefficient of water; default is 0.99
-K1k2=<value>
Set the K1/k2 for oxygen; by default the K1/k2 is estimated from
OER and saturation curves for hemoglobin and myoglobin
-Sao2=<value>
Saturation of arterial blood hemoglobin; default is 0.97
-p50Hb=<value>
Half-saturation pressure for hemoglobin; default is 3.6 kPa
-p50Mb=<value>
Half-saturation pressure for myoglobin; default is 0.319 kPa
-nHb=<value>
Hill coefficient for hemoglobin; default is 2.7
-Mb=<value>
Concentration of myoglobin in muscle; default is 4.7 mg/g
-Hb=<value>
Concentration of hemoglobin in blood; default is 150 mg/g
Calculated tissue activities are written in the specified file with
these data columns. Columns 2-6 will be saved optionally (-sub):
0) Time
1) Total regional radioactivity concentration (2+3+4+5+6)
2) Labeled [O2] in tissue region
3) Labeled [H2O] in tissue region
4) Concentration of arterial radioactivity in tissue region
5) Venous labeled [O2] in tissue region
6) Venous labeled [H2O] in tissue region
References:
1. Nuutila P, Peltoniemi P, Oikonen V, Larmola K, Kemppainen J, Takala T,
Sipila H, Oksanen A, Ruotsalainen U, Bolli GB, Yki-Jarvinen H.
Enhanced stimulation of glucose uptake by insulin increases
exercise-stimulated glucose uptake in skeletal muscle in humans: studies
using [15O]O2, [15O]H2O, [18F]fluoro-deoxy-glucose, and positron emission
tomography. Diabetes 2000; 49:1084-1091.
2. Oikonen V, Nuutila P, Sipilä H, Tolvanen T, Peltoniemi P, Ruotsalainen U.
Quantification of oxygen consumption in skeletal muscle with PET and
oxygen-15 bolus. Eur J Nucl Med. 1998; 25: 1151.
3. Oikonen V. Modelling of low oxygen consumption. In: J. Knuuti, J. Rinne,
P.Tenhonen (ed.), Medical Applications of Cyclotrons VIII. Abstracts of
the VIII Symposium on the Medical Applications of Cyclotrons.
Annales Universitatis Turkuensis D346:16, 1999.
See also:
fit_mo2,
o2metab,
o2_p2w,
fit_o2bl,
avgbolus,
fr4sim
Keywords: DFT, simulation, oxygen, skeletal muscle
This program comes with ABSOLUTELY NO WARRANTY. This is free software, and
you are welcome to redistribute it under GNU General Public License.