fit_fexp 1.1.1 © 2006-2010 by Turku PET Centre
Fits the following exponential function to a fraction curve of unchanged
(parent) tracer in plasma, where fractions are between 0 and 1 (1,2).
-B*x -C*x
f(x) = 1 - A * (2 - e -e ) , where 0<A<=1 , B>0 , C>0
Usage: fit_fexp [Options] <Fraction file> [Fit file]
General options:
-ND Some fractions are known to exceed 1, not divided by 100.
-h or --help
Print this message and exit.
--build or --version
Print software build information and exit.
--silent
Program works silently, printing only error and warning messages.
--verbose
Program prints more information about what it is doing.
Options to set weights:
-W1 All weights are set to 1.0; by default, sample times are used to
calculate weights unless weights are not supplied in fraction file.
-WC The last data column contains sample weights.
Fraction datafile must contain two columns, sample times and fractions
of parent tracer. Weights can be specified as specified in DFT format (4);
any additional columns are ignored.
Lines that start with a '#' are not read from the datafile.
Program writes the fit start and end times, nr of points, WSS/n,
and parameters of the fitted function to the FIT file (5).
References:
1. Fitting the fractions of parent tracer in plasma.
http://www.turkupetcentre.net/analysis/doc/fraction_fit.html
2. Kropholler MA, Boellaard R, Schuitemaker A, van Berckel BNM, Luurtsema G,
Windhorst AD, Lammertsma AA. Development of a tracer kinetic plasma input
model for (R)-[11C]PK11195 brain studies. J Cereb Blood Flow Metab. 2005;
25(7): 842-851.
4.
http://www.turkupetcentre.net/analysis/doc/format_dft.html
5.
http://www.turkupetcentre.net/analysis/doc/format_fit.html
See also:
fit2dat,
metabcor,
avgfract,
fit_hill,
fit_ppf,
fit_exp,
dft2svg
Keywords: input, modelling, simulation, metabolite correction
This program comes with ABSOLUTELY NO WARRANTY. This is free software, and
you are welcome to redistribute it under GNU General Public License.