fit_frtm 2.6.0 © 1999-2013 by Turku PET Centre
Estimates R1 (=K1/K1'), k2, k3, and BPnd (binding potential) using
the (full) reference tissue compartment model FRTM/RTCM (1,3). Assumption
is that K1/k2 is the same in all brain regions, but one-tissue compartment
model with plasma input does not need to fit the data satisfactorily
as is assumed in SRTM (2), and Cref(t) is not assumed to be the same as
Cfree(t) as is assumed in the ratio methods.
This program uses nonlinear regression in model fitting.
Parameters:
1) Tissue TAC file
2) Name of reference region in tissue file, or name of file
containing reference tissue TAC
3) Fit time (in minutes from injection)
4) Result file (4)
Options:
-DVR
Instead of BPnd, program saves the DVR (=BPnd+1) values.
-lim=<filename>
Specify the constraints for model parameters;
This file with default values can be created by giving this
option as the only command-line argument to this program.
-SD[=<y|N>]
Standard deviations are calculated and saved in results (y), or
not calculated (n).
-CL[=<y|N>]
95% Confidence limits are calculated and saved in results (y), or
not calculated (n).
-fit=<Filename>
Fitted regional TACs are written in file.
-svg=<Filename>
Fitted and measured TACs are plotted in specified SVG file (5).
-h or --help
Print this message and exit.
--version or --build
Print software build information and exit.
--silent
Program works silently, printing only error and warning messages.
--verbose
Program prints more information about what it is doing.
If datafile contains weights, those are used in the fitting.
Values of R1, k2, and BPnd are written in the specified result file.
Fitted curves are written in DFT format, if filename is given.
Example 1: file a789.dft contains regions-of-interest and reference region,
with name 'cer all'. The whole time range is used in the fit.
fit_frtm a789.dft 'cer all' 999 a789.res
Example 2: Reference region TAC is in a separate file, a789ref.dft.
Standard deviations and confidence limits are also estimated.
fit_frtm -SD=y -CL=y a789.dft a789ref.dft 999 a789.res
References:
1. Cunningham VJ, Hume SP, Price GR, Ahier RG, Cremer JE, Jones AKP.
Compartmental analysis of diprenorphine binding to opiate receptors
in the rat in vivo and its comparison with equilibrium data in vitro.
J Cereb Blood Flow Metab 1991;11:1-9.
2. Lammertsma AA, Hume SP. Simplified reference tissue model for PET
receptor studies. NeuroImage 1996;4:153-158.
3. Oikonen V, Sederholm K. TPCMOD0002: Model equations for reference tissue
compartmental models.
http://www.turkupetcentre.net/reports/tpcmod0002.pdf
4. File format specification: Result file.
http://www.turkupetcentre.net/formats/format_res_1_0_0.pdf
5. Scalable Vector Graphics (SVG) 1.1 Specification.
http://www.w3.org/TR/SVG/
See also:
dftweigh,
rescoll,
logan,
fit_srtm,
regbfbp,
r2t_rctm
Keywords: DFT, modelling, binding potential, BP, RTCM, reference input
This program comes with ABSOLUTELY NO WARRANTY. This is free software, and
you are welcome to redistribute it under GNU General Public License.