fit_hiad 0.3.5 © 2008-2010 by Turku PET Centre
Fits the Hill and Hill derivative sum function to the PET
time-activity curves (TACs):
f(x) = A * { [n*xt^(n-1)]/[h^n+xt^n] - [n*xt^(2*n-1)]/[h^n+xt^n]^2
+ [k*xt^n]/[h^n+xt^n] } , where xt=x-dt and n>=1
Usage: fit_hiad [Options] <TAC file> [Fit parameter file]
Options:
-Hill
Hill function without Hill derivative is fitted;
f(x) = (A*xt^n)/(h^n+xt^n)
-fast or -safe
Speed up the fitting but increase the chance of failure, or
increase the reliability at the cost of computing time
-W1
All weights are set to 1.0; by default, sample times are used to
calculate weights unless weights are not supplied in fraction file
-k=<value>
Parameter k is constrained to given value; setting k to zero causes
the function to approach zero
-dlow=<time>
Penalize Hill derivative higher than 1% of total tissue activity
after specified time
-delay=<<value>|mean|median>
Delay time (dt) is constrained to specified value or to mean or median
of all TACs
-fit=<Filename>
Fitted TACs are written in DFT format
-svg=<Filename>
Fitted and measured TACs are plotted in specified SVG file
-h or --help
Print this message and exit
--version or --build
Print software build information and exit
--silent
Program works silently, printing only error and warning messages
--verbose
Program prints more information about what it is doing
Program writes the fit start and end times, nr of points, WSS/n,
and parameters of the fitted function to the result (fit) file,
in format:
http://www.turkupetcentre.net/analysis/doc/format_fit.html
See also:
fit2dat,
fit2res,
dftweigh,
dft2svg,
regderiv,
fit_exp,
fit_ratf
Keywords: DFT, input, modelling, simulation
This program comes with ABSOLUTELY NO WARRANTY. This is free software, and
you are welcome to redistribute it under GNU General Public License.