fitk2 1.3.4 © 2004-2013 by Turku PET Centre
Non-linear fitting of one-tissue compartment model to plasma and tissue
time-activity curves (TACs) to estimate K1, k2 and Vb.
Parameters:
1) Plasma file (corrected for labeled metabolites)
2) Blood file
3) Tissue TAC file (*.dft)
4) Fit end time (duration)
5) Result file
Options:
-lim[=<filename>]
Specify the constraints for model parameters;
This file with default values can be created by giving this
option as the only command-line argument to this program.
Without filename the default values are printed on screen.
-SD[=<y|N>]
Standard deviations are calculated and saved in results (Y, default),
or not calculated (n).
Program runs a lot faster if SD and CL are not calculated.
-CL[=<y|N>]
95% Confidence limits are calculated and saved in results (y), or
not calculated (N, default).
-Vb=<Vb(%)>
Enter a fixed Vb; fitted by default.
-<BPnd|BPp|DVR>=<Reference region name or filename>
Optional reference region is used to calculate BPnd, BPp, or DVR;
BPnd=DVroi/DVref-1, BPp=DVroi-DVref, and DVR=DVroi/DVref
-fit=<Filename>
Fitted regional TACs are written in DFT format.
-svg=<Filename>
Fitted and measured TACs are plotted in specified SVG file.
-h or --help
Print this message and exit.
--version or --build
Print software build information and exit.
--silent
Program works silently, printing only error and warning messages.
--verbose
Program prints more information about what it is doing.
Example 1: estimate K1, K1/k2 and Vb, no estimation of parameter SD
fitk2 -sd=n a919ap.kbq a919ab.kbq a919.dft 60 a919k2.res
Example 2: estimate K1 and DV (=K1/k2); Vb is constrained to 0%%;
DVRs are calculated by dividing DVs by the DV of region 'cer'
fitk2 -Vb=0 -R=cer p25apc.kbq none p25.dft 60 p25_k2.res
See also:
logan,
lhsoldv,
fitk2di,
fitk4,
fit_h2o,
p2t_v3c,
dftweigh,
dftcbv
Keywords: DFT, modelling, distribution volume, reversible uptake
This program comes with ABSOLUTELY NO WARRANTY. This is free software, and
you are welcome to redistribute it under GNU General Public License.