fitk2di 0.4.0 © 2010-2013 by Turku PET Centre
Non-linear fitting of dual input compartment model, with one tissue
compartment for both tracers (parent and metabolite):
_____ K1p _____
| Cap | ----> | Ctp |
|_____| <---- |_____|
k2p |
km|
v
_____ K1m _____
| Cam | ----> | Ctm |
|_____| <---- |_____|
k2m
Parameters:
1) Parent plasma TAC file
2) Metabolite plasma TAC file
3) Blood TAC file (enter NONE if Vb is pre-corrected)
4) Tissue TAC file
5) Fit end time (duration)
6) Result file
Options:
-lim[=<filename>]
Specify the constraints for model parameters;
This file with default values can be created by giving this
option as the only command-line argument to this program.
Without filename the default values are printed on screen.
-SD[=<y|N>]
Standard deviations are calculated and saved in results (y),
or not calculated (N, default).
Program runs a lot faster if SD and CL are not calculated.
-CL[=<y|N>]
95% Confidence limits are calculated and saved in results (y), or
not calculated (N, default).
-Vb=<Vb(%)>
Enter a fixed Vb; fitted by default.
-ref=<Reference region name or filename>
Specified reference region is fitted using different set of model
parameter constraints; not necessary if reference region is given
with one of the following options -BPnd, -BPp, or -DVR.
-<BPnd|BPp|DVR>=<Reference region name or filename>
Optional reference region is used to calculate BPnd, BPp, or DVR;
BPnd=DVroi/DVref-1, BPp=DVroi-DVref, and DVR=DVroi/DVref
-refVfm=refVfp
In reference region Vfm is set to equal Vfp=1.
-mc=<Filename>
Fit-based metabolite corrected regional TACs are written in DFT format.
-fit=<Filename>
Fitted regional TACs are written in DFT format.
-svg=<Filename>
Fitted and measured TACs are plotted in specified SVG file.
-h or --help
Print this message and exit.
--version or --build
Print software build information and exit.
--silent
Program works silently, printing only error and warning messages.
--verbose
Program prints more information about what it is doing.
Example 1: fitting with default settings
fitk2di ia919apc.kbq ia919apm.kbq ia919ab.kbq ia919.dft 60 a919k2di.res
Example 2: Vb is constrained to 0%; DVRs are calculated by dividing DVs
by the DV of region 'cer'
fitk2di -Vb=0 -R=cer p25apc.kbq p25apm.kbq none p25.dft 60 p25k2di.res
See also:
fitk2,
logan,
fitk4,
p2t_di,
dftweigh,
dftcbv
Keywords: DFT, modelling, distribution volume, reversible uptake, dual-input
This program comes with ABSOLUTELY NO WARRANTY. This is free software, and
you are welcome to redistribute it under GNU General Public License.