fitk2wm 0.3.0 © 2004,2005 by Turku PET Centre
Non-linear fitting of one-tissue compartment model to plasma and
tissue time-activity curves (TACs) to estimate K1, k2 and Vb.
In addition, all regions are assumed to contain white matter (WM);
the WM volume fraction is also estimated as one of parameters.
Parameter estimates are restricted to the following values:
Region K1 K1/k2 fWM(%) Vb(%)
All 0 - 10 1e-5 - 500 0-75 0-8
Parameters:
1) Plasma file (corrected for labeled metabolites)
2) Blood file
3) Tissue TAC file (*.dft)
4) Name of WM region
5) Fit end time (duration)
6) Result file
7) Fitted tissue TAC file (optional)
Options:
-SD Standard deviations are calculated and saved in results (default)
-CL 95% Confidence limits are calculated and saved in results
-n SDs or confidence limits are not calculated nor reported
-Vb=<Vb(%)>
Enter a fixed Vb; fitted by default.
-R=<Reference region name or filename>
Optional reference region is used only to calculate DVR.
e.g.: fitk2wm a00919ap.kbq a00919ab.kbq a00919.dft wm 60 a00919k2.res
or: fitk2wm -Vb=4.5 -R=cer p02apc.kbq p02ab.kbq p02.dft wm 60 p02k2.htm
See also:
logan,
lhsol,
fitk2,
fitk4,
fit_h2o,
p2t_v3c,
dftweigh,
dftcbv
Keywords: DFT, modelling, distribution volume, white matter