fitk3 3.3.4 © 2000-2013 by Turku PET Centre
Non-linear fitting of two-tissue compartment model to plasma and tissue
time-activity curves (TACs) to estimate K1, k2, k3, and optionally Vb.
______ ___________________
| | K1 | k3 |
| | --> | -------> |
| Ca | <-- | C1 <------- C2 |
| | k2 | k4=0 |
|______| |___________________|
Parameters:
1) Plasma file (corrected for labeled metabolites)
2) Blood file
3) Tissue TAC file (*.dft)
4) Fit end time (duration)
5) Result file
Options:
-lim[=<filename>]
Specify the constraints for model parameters;
This file with default values can be created by giving this
option as the only command-line argument to this program.
Without filename the default values are printed on screen.
-SD[=<y|N>]
Standard deviations are calculated and saved in results (y),
or not calculated (N, default).
Program runs a lot faster if SD and CL are not calculated.
-CL[=<y|N>]
95% Confidence limits are calculated and saved in results (y), or
not calculated (N, default).
-Vb=<Vb(%)>
Enter a fixed Vb; fitted by default.
-r=<Reference region name or filename>
Optional reference region is used to constrain K1/k2 in other regions;
Also k3 is fitted to reference region data, thus any large region
(for example cortex) can be used here.
-fit=<Filename>
Fitted regional TACs are written in DFT format.
-svg=<Filename>
Fitted and measured TACs are plotted in specified SVG file.
-h or --help
Print this message and exit.
--version or --build
Print software build information and exit.
--silent
Program works silently, printing only error and warning messages.
--verbose
Program prints more information about what it is doing.
Example 1: estimate K1, K1/k2, k3 and Vb
fitk3 ua919ap.kbq ua919ab.kbq ua919.dft 60 ua919k3.res
Example 2: estimate K1 and k3; Vb is constrained to 4.5%% and K1/k2 is
constrained to K1/k2 estimated from region 'occip'
fitk3 -Vb=4.5 -r=occip ua919ap.kbq ua919ab.kbq ua919.dft 60 ua919.res
See also:
patlak,
lhsol,
p2t_v3c,
dftweigh,
extrapol,
dftcbv,
rescoll
Keywords: TAC, modelling, irreversible uptake, k3, Ki
This program comes with ABSOLUTELY NO WARRANTY. This is free software, and
you are welcome to redistribute it under GNU General Public License.