fitk5 0.2.2 © 2012-2013 by Turku PET Centre
Non-linear fitting of three-tissue compartment model to plasma and tissue
time-activity curves (TACs) to estimate K1, k2, k3, k4, k5, and
optionally Vb.
Model with two of tissue compartments in parallel:
_____ ____ ____
| | K1 | | k3 | |
| Ca | ----> | | ----> | C2 |
|_____| | | <---- |____|
_____ | C1 | k4 ____
| | | | | |
| Cv | <---- | | ----> | C3 |
|_____| k2 |____| k5 |____|
Model with compartments in series:
_____ ____ ____ ____
| | K1 | | k3 | | k5 | |
| Ca | ----> | | ----> | C2 | ----> | C3 |
|_____| | | <---- |____| |____|
_____ | C1 | k4
| | | |
| Cv | <---- | |
|_____| k2 |____|
Parameters:
1) Plasma file (corrected for labeled metabolites)
2) Blood file
3) Tissue TAC file (*.dft)
4) Fit end time (duration)
5) Result file
Options:
-lim[=<filename>]
Specify the constraints for model parameters;
This file with default values can be created by giving this
option as the only command-line argument to this program.
Without filename the default values are printed on screen.
-SD[=<y|N>]
Standard deviations are calculated and saved in results (y),
or not calculated (N, default).
Program runs a lot faster if SD and CL are not calculated.
-CL[=<y|N>]
95% Confidence limits are calculated and saved in results (y), or
not calculated (N, default).
-model=<parallel|series>
Specify the model that is fitted to data; compartments in parallel
(default) or in series.
-Vb=<Vb(%)>
Enter a fixed Vb; fitted by default.
-fit=<Filename>
Fitted regional TACs are written in DFT format.
-svg=<Filename>
Fitted and measured TACs are plotted in specified SVG file.
-h or --help
Print this message and exit.
--version or --build
Print software build information and exit.
--silent
Program works silently, printing only error and warning messages.
--verbose
Program prints more information about what it is doing.
Example 1: estimate K1, K1/k2, k3, k3/k4, k5, and Vb,
fitk5 ua919ap.kbq ua919ab.kbq ua919.dft 60 ua919k5.res
See also:
patlak,
p2t_v3c,
fitk3,
fitk4,
dftweigh,
dftcbv,
rescoll
Keywords: TAC, modelling, irreversible uptake, k5, Ki
This program comes with ABSOLUTELY NO WARRANTY. This is free software, and
you are welcome to redistribute it under GNU General Public License.