fitkloss 3.0.2 © 2002-2013 by Turku PET Centre
Non-linear fitting of two-tissue compartment model with kLoss or k4
to plasma and tissue time-activity curves (TACs) to estimate K1, k2, k3,
kLOSS or k4, and optionally Vb.
kLoss-model:
____ ____ ____
| Ca | K1 | | k3 | |
|____| ----> | C1 | ----> | C2 |
| | <---- |____| | |
| Cv | k2 | |
| | kLoss | |
|____| <----------------- |____|
k4-model:
____ ____ ____
| Ca | K1 | | k3 | |
|____| ----> | C1 | ----> | C2 |
| Cv | <---- | | <---- | |
|____| k2 |____| k4 |____|
Parameters:
1) Plasma file (corrected for labeled metabolites)
2) Blood file
3) Tissue TAC file
4) Fit end time (duration)
5) Result file
Options:
-lim[=<filename>]
Specify the constraints for model parameters;
This file with default values can be created by giving this
option as the only command-line argument to this program.
Without filename the default values are printed on screen.
-SD[=<y|N>]
Standard deviations are calculated and saved in results (y),
or not calculated (N, default).
Program runs a lot faster if SD and CL are not calculated.
-CL[=<y|N>]
95% Confidence limits are calculated and saved in results (y), or
not calculated (N, default).
-model=<k4|kloss>
Specify the model that is fitted to data; kLoss model by default.
-Vb=<Vb(%)>
Enter a fixed vascular blood volume Vb; fitted by default.
-f=<K1/F>
K1/F-ratio; by default flow is ignored (F>>K1).
-a=<fA%>
Arterial volume fraction; 30 by default; effective only with -f.
-fit=<Filename>
Fitted regional TACs are written in DFT format.
-svg=<Filename>
Fitted and measured TACs are plotted in specified SVG file.
-h or --help
Print this message and exit
--version or --build
Print software build information and exit
--silent
Program works silently, printing only error and warning messages
--verbose
Program prints more information about what it is doing.
Example:
fitkloss s919ap.dat s919ab.dat s919.dft 999 s919.res
If datafile contains weights, those are used in the fitting.
Model parameters are written in the specified result file.
See also:
dftweigh,
fitk4,
fitk3,
patlak,
logan,
p2t_loss,
dft2svg,
rescoll
Keywords: TAC, modelling, loss rate, enzyme activity
This program comes with ABSOLUTELY NO WARRANTY. This is free software, and
you are welcome to redistribute it under GNU General Public License.