fitmetab 0.3.0 © 2007-2010 by Turku PET Centre

Fits the parameters of compartment model for plasma input metabolite correction for PET (1, 2). Two data files (3) are needed for the model fit: the total time-activity concentration curve (parent tracer + radioactive metabolites), and the measured fractions of parent tracer to total plasma activity. Usage: fitmetab [Options] <Plasma file> <Fraction file> <Parameter file> Options: -fract=<Filename> Write fitted fraction curve in specified file -parent=<Filename> Write the TAC of parent tracer in plasma in specified file -metab=<Filename> Write the TAC of metabolite in plasma in specified file -nd Some fractions are known to exceed 1, not divided by 100 -model=<TPC|Huang> Select the metabolite model, either TPC (default), or Huang with single plasma metabolite -h or --help Print this message and exit --build or --version Print software build information and exit --silent Program works silently, printing only error and warning messages --verbose Program prints more information about what it is doing. If the sample times in plasma file are in seconds, the units of rate constants will be specified as 1/sec. For accurate results, plasma data should have a frequent sampling. Parameter file will contain: -Name of metabolite model -Model parameter values For example, model := TPCMOD0009C km := 0.8 k1m := 0.5 k2m := 0.4 k3m := 0.1 k4m := 0 Accepted metabolite models are: -TPC metabolite model (2) References: 1. Lammertsma AA, Hume SP, Bench CJ, Luthra SK, Osman S, Jones T. Measurement of monoamine oxidase B activity using L-[11C]derenyl: Inclusion of compartmental analysis of plasma metabolites and a new model not requiring measurement of plasma metabolites. In: Quantification of Brain Function: Tracer Kinetics and Image Analysis in Brain PET (Uemura K, Lassen NA, Jones T, Kanno I, eds) Amsterdam, Excerpta Medica (pp) 313-318, 1993. 2. Oikonen V. New model for plasma metabolites. http://www.turkupetcentre.net/reports/tpcmod0009_app_c.pdf 3. DFT format. http://www.turkupetcentre.net/analysis/doc/format_dft.html See also: metabcor, simmetab, fit_hill, fit_fexp, dft2svg Keywords: DFT, input, metabolite correction, simulation This program comes with ABSOLUTELY NO WARRANTY. This is free software, and you are welcome to redistribute it under GNU General Public License.