heartcor 1.1.0 © 2007-2013 by Turku PET Centre
Correction of regional tissue and blood time-activity curves (TACs)
measured with PET for recovery and spillover fractions, and contribution
of blood activity in vascular space (10%) (Henze et al., 1983).
This method works properly, if regions-of-interest (ROIs) are drawn
in the middle of cavity and muscle, excluding the border areas.
Method is valid when cavity radius >> wall thickness and FWHM/2.36.
Command-line parameters:
1) Datafile that contains at least three columns: sample times and TACs
of myocardial cavity and myocardium. Corrections based on these TACs
are applied to any additional TACs in the file; for file format
see
http://www.turkupetcentre.net/analysis/doc/format_dft.html
2) Name or number of regional TAC representing cavity/blood
3) Name or number of regional TAC representing whole myocardium
surrounding cavity
4) Diameter of cavity (mm)
5) Myocardial wall thickness (mm)
6) Image resolution in PET image (FWHM, mm)
7) Output datafile
Options:
-Vb=<Vascular volume fraction>
Set vascular volume fraction (0-0.9) in tissue; by default Vb=0.1
-sim[ulate]
Recovery and spillover errors are simulated and added to initially,
non-affected data, originating from compartment model simulations
-h or --help
Print this message and exit
-v, --version, or --build
Print software build information and exit
--silent
Program works silently, printing only warnings and error messages.
Example:
heartcor s6368dy.dft lv myo 52 10 10 s6368dy_cor.dft
Reference:
1. Henze E, Huang S-C, Ratib O, Hoffman E, Phelps ME, Schelbert HR.
Measurements of regional tissue and blood-pool radiotracer
concentrations from serial tomographic images of the heart.
J Nucl Med. 1983;24:987-996.
See also:
fitmbf,
patlak,
logan,
simimyoc
Keywords: myocardium, cavity, spill-over, recovery, modelling, simulation
This program comes with ABSOLUTELY NO WARRANTY. This is free software, and
you are welcome to redistribute it under GNU General Public License.