lassenp 0.1.1 © 2010,2011 by Turku PET Centre
Calculates drug occupancy from distribution volumes of PET tracer
without reference region using Lassen plot (1,2).
Usage: lassenp [Options] <DV-result file1> <DV-result file2> <Occ file>
Options:
-c1=<Drug concentration in study 1>
-c2=<Drug concentration in study 2>
Occupancy is calculated without baseline study (not yet implemented)
-svg=<Filename>
Plot is written in specified file in Scalable Vector Graphics format
-h or --help
Print this message and exit
--version or --build
Print software build information and exit
--silent
Program works silently, printing only error and warning messages
--verbose
Program prints more information about what it is doing.
References:
1. Lassen NA, Bartenstein PA, Lammertsma AA, Prevett MC, Turton DR,
Luthra SK, Osman S, Bloomfield PM, Jones T, Patsalos PN, O'Connell MT,
Duncan JS, Andersen JV. Benzodiazepine receptor quantification in vivo
in humans using [11C]flumazenil and PET: application of the steady-state
principle. J Cereb Blood Flow Metab. 1995;15:152-165.
2. Cunningham VJ, Rabiner EA, Slifstein M, Laruelle M, Gunn RN. Measuring
drug occupancy in the absence of a reference region: the Lassen plot
re-visited. J Cereb Blood Flow Metab. 2010;30:46-50.
See also:
logan,
fitk4,
reslist,
resdel,
rescoll,
resdiff
Keywords: modelling, receptor occupancy, Lassen plot, distribution volume
This program comes with ABSOLUTELY NO WARRANTY. This is free software, and
you are welcome to redistribute it under GNU General Public License.