mapmin 1.0.2 © 2002-2007 by Turku PET Centre

Program studies the map of WSS minima of non-linear compartmental models applied to PET tissue and plasma data. The following procedure until the frequency of finding new minima gets lower than a specified value: 1) make initial parameter values using randon number generator 2) make delta values using randon number generator 3) find local minimum using Powell-Brent or Hooke-Jeeves method 4) save minimum, if differs from the previous saved ones 5) repeat from 1) until the stop criteria are fulfilled. Command-line parameters: 1) Parameter file (see below) 2) Plasma file 3) Blood file 4) Tissue TAC file (*.dft) 5) Fit end time (duration) 6) Report file: list of all minima 7) Result file: parameters at global minimum e.g.: mapmin par.set a00919ap.dat a00919ab.dat a00919.dft 999 a00919.log a00919.res The parameter file contents must be exactly as follows: 1) Model identifier: PR= parallel (receptor) model with parameters Va, K1, K1/k2, k3, k3/k4, k5, k5/k6 P = parallel (raceptor) model with parameters Va, K1, k2, k3, k4, k5, k6 SR= serial (metabolism) model with parameters Va, K1, K1/k2, k3, k3/k4, k5, k5/k6 S= serial (metabolism) model with parameters Va, K1, k2, k3, k4, k5, k6 LR= kLoss model with parameters Va, K1 K1/k2 k3 kLoss L = kLoss model with parameters Va, K1, k2, k3, kLoss 2) Lower and upper limits for each of the parameters Parameter can be fixed to a certain value by setting equal limits; fixing a ratio k3/k4 or k5/k6 to zero sets k4 or k6 to zero. 3) Value of K1/F (0, if blood flow is not considered) 4) Number of sampled points (prfmNr) Results are appended to the end of files, if they exist already. Fitted curves are written in DFT format, if filename is given.