p2t_loss 1.2.0 © 2001-2012 by Turku PET Centre
Simulation of PET tissue time-radioactivity concentration curve (TAC)
from arterial plasma (Ca) TAC, based on two-tissue compartmental model
with a loss of tracer from the second compartment to plasma.
____ k1 ____ k3 ____
| Ca | ----> | C1 | ----> | C2 |
|____| |____| |____|
| |
| k2 | kLoss
v v
dC1(t)/dt = K1*Ca(T) - (k2+k3)*C1(T)
dC2(t)/dt = k3*C1(T) - kLoss*C2(T)
Ct(T) = C1(T) + C2(T) + C3(T)
Parameters:
1) Plasma TAC filename
2-5) k1, k2, k3, kLoss
6) Filename for simulated TACs
Options:
-sub | -nosub
TACs of sub-compartments (C1 and C2) are written (-sub, default)
or not written (-nosub) into the output file.
-h or --help
Print this message and exit.
-v, --version or --build
Print software build information and exit.
--silent
Program works silently, printing only error and warning messages.
--verbose
Program prints more information about what it is doing.
If the times in plasma file are in seconds, the units of rate constants
must be specified as 1/sec.
For accurate results, plasma TAC should have very short sampling intervals.
Results are saved in DFT format, where the TACs are:
1) Total tissue activity concentration (Ct)
2) Activity concentration in 1st tissue compartment (C1)
3) Activity concentration in 2nd tissue compartment (C2)
See also:
p2t_3c,
p2t_v3c,
dftadd,
dftren,
fr4sim,
dft2csv,
dft2img
Keywords: DFT, simulation, compartmental model, loss rate
This program comes with ABSOLUTELY NO WARRANTY. This is free software, and
you are welcome to redistribute it under GNU General Public License.