p2t_p3c 1.1.1 © 2001-2006 by Turku PET Centre
Simulation of PET tissue time-radioactivity concentration curve (TAC)
from arterial plasma (Ca) TAC based on three-tissue compartmental model,
where the second and third compartments are parallel, often used to
represent specific and non-specific binding.
____ k1 ____ k3 ____
| Ca | ----> | C1 | ----> | C2 |
|____| <---- |____| <---- |____|
k2 k4
| ^
k5 | | k6 dC1(t)/dt = k1*Ca(T) - (k2+k3+k5)*C1(T) +
v | k4*C2(T) + k6*C3(T)
____ dC2(t)/dt = k3*C1(T) - k4*C2(T)
| C3 | dC3(t)/dt = k5*C1(T) - k6*C3(T)
|____| Ct(T) = C1(T) + C2(T) + C3(T)
Parameters:
1) Plasma TAC filename
2-7) k1, k2, k3, k4, k5, k6
8) Filename for simulated TACs
Options:
-nosub
TACs of sub-compartments (C1, C2 and C3) are not written into output file.
-h or --help
Print this message and exit.
-v, --version or --build
Print software build information and exit.
--silent
Program works silently, printing only error and warning messages.
If the times in plasma file are in seconds, the units of rate constants
must be specified as 1/sec.
For accurate results, plasma data should have very short (e.g. 0.1 min)
time 'frames'.
To reduce the model, k5 and/or k3 can be set to 0.
Results are saved in DFT format, where the TACs are:
1) Total tissue activity concentration (Ct)
2) Activity concentration in 1st tissue compartment (C1)
3) Activity concentration in 2nd tissue compartment (C2)
4) Activity concentration in 3rd tissue compartment (C3)
See also:
p2t_3c,
p2t_vp3c,
dftadd,
dftren,
fr4sim,
dft2img
Keywords: DFT, simulation
This program comes with ABSOLUTELY NO WARRANTY. This is free software, and
you are welcome to redistribute it under GNU General Public License.