regbfh2o 0.2.0 © 2013 by Turku PET Centre
Basis function (BS) fitting of one-tissue compartmental water model to
PET [O-15]H2O study data (Boellaard et al., 2005).
The model parameters are blood flow (F), partition coefficient (pWater),
arterial blood volume (Va) and time delay (delayT). Venous radioactivity
is assumed to be the same as the tissue concentration.
Extraction factor of water is assumed to be 1.0.
The blood flow obtained using PET [O-15]H2O techniques reflects tissue
perfusion, since the method is dependent on the tissue exchange of
labelled water. Non-nutritive flow (blood flowing through arteriovenous
shunts) is not measured (Lammertsma & Jones, 1983).
Command line parameters:
1) Blood H2O file (corrected for time delay and physical decay)
2) Tissue TAC file (corrected for physical decay)
3) Fit duration (sec)
4) Result file
General options:
-ml or -dl
In results the units of F and Va will be given per mL or per dL,
respectively. By default, units are per dL.
-fpt
Blood flow (perfusion) is reported per perfusable tissue volume
(PET volume minus vascular volume). By default perfusion is reported
per PET volume.
-Va=<Va(%)>
Enter a fixed Va; fitted by default.
-pH2O=<Partition coefficient for water>
Enter the true partition coefficient for water to report perfusion as
F=k2*pH2O instead of default F=K1; apparent pH2O is fitted in any case.
-svg=<Filename>
Plots of original and fitted TACs are written in specified file in
Scalable Vector Graphics (SVG) 1.1 format; specification in
http://www.w3.org/TR/SVG/
-fit=<Filename>
Fitted regional TACs are written in specified file.
-h or --help
Print this message and exit
-v, --version or --build
Print software build information and exit
--silent
Program works silently, printing only error and warning messages
--verbose
Program prints more information about what it is doing.
Options for setting basis functions:
-k2min=<Min k2> and -k2max=<Max k2>
Enter the minimum and maximum k2 in units 1/min (for example
0.01 and 2.5).
-fmin=<Min K1> and -fmax=<Max K1>
Enter the minimum and maximum perfusion value; defaults are
0.5 and 400 ml/(dl*min), respectively.
-pmin=<Min p> and -max=<pmax>
Enter the minimum and maximum value for apparent partition coefficient
for water; defaults are 0.3 and 1.0 ml/ml, respectively.
-nr=<value>
Set number of basis functions; default is 5000.
-bf=<filename>
Basis function curves are written in specified file.
Example: regbfh2o uo1234bl.kbq uo1234.dft 999 uo1234f.res
Times must be in seconds in all PET data files, unless specified inside
the files.
References:
1. Boellaard R et al. Mol Imaging Biol. 2005;7:273-285.
2. Lammertsma AA, Jones T. J Cereb Blood Flow Metab. 1983;3:416-424.
See also:
b2t_h2o,
fit_h2o,
regbfh2o,
imgflow,
arlkup,
fitk2,
dftweigh
Keywords: DFT, TAC, modelling, perfusion, blood flow, radiowater
This program comes with ABSOLUTELY NO WARRANTY. This is free software, and
you are welcome to redistribute it under GNU General Public License.