regfur 1.2.0 © 2007-2013 by Turku PET Centre
Calculation of Fractional Uptake Rate (FUR) or FUR-based Metabolic Rate (MR)
from regional PET TACs. Information on FUR in:
http://www.turkupetcentre.net/modelling/methods/fur.html
Parameters:
1) Input file (Plasma TAC)
2) Regional TAC file
3-4) FUR calculation start and stop time (min);
set both to zero to use the whole time range from regional data
5) FUR or MR result file
Options for calculation of metabolic rate:
-Ca=<value>
Concentration of native substrate in arterial plasma (mM),
for example plasma glucose in [18F]FDG studies.
With this option the metabolic rate (umol/(min*100 g)) is calculated.
-LC=<value>
Lumped Constant in MR calculation; default is 1.0.
-density=<value>
-d=<value>
Tissue density in MR calculation; default is 1.0 g/ml.
General options:
-curve=<filename>
FUR as a function of time is written in specified file; this can be
used to study the time-dependence of FUR estimates.
-it=<Time (min)>
Input AUC is normally calculated from 0 to the middle time of FUR
calculation time; in special cases this option can be used to
calculate it from 0 to the specified time instead.
-deriv[ative]
Tentative option for calculating FUR as ratio of tissue derivative and
plasma. This does not affect the FUR curve made with option -curve.
-h or --help
Print this message and exit.
-v, --version or --build
Print software build information and exit.
--silent
Program works silently, printing only error and warning messages.
--verbose
Program prints more information about what it is doing
Example 1. Calculation of FUR from dynamic PET data from 45 to 60 min:
regfur ua2918ap.kbq ua2918dy1.dft 45 60 ua2918fur.res
Example 2. Calculation of glucose uptake, when tissue density is 1.04,
plasma glucose concentration is 5.2 mM, lumped constant is 0.52, from
a static (one frame) scan:
regfur -Ca=5.2 -LC=0.52 -d=1.04 a864ap.kbq a864dy1.dft 0 0 a864mrglu.res
FUR and MR results are saved in result file format by default, but if
filename extension is set to .dft or .html, results are saved in
regional TAC or HTML table format, respectively.
Format of the supported plasma and regional TAC data files are specified in
http://www.turkupetcentre.net/analysis/doc/format_dft.html and result file
in
http://www.turkupetcentre.net/analysis/doc/format_res.html
The unit of FUR is (mL plasma)/(min*(mL tissue)) by default, and
umol/(min*100 g) if metabolic rate is calculated.
See also:
patlak,
dftinteg,
dftcalc,
dfttime,
dftsuv,
rescoll,
imgfur
Keywords: DFT, modelling, FUR, retention index, irreversible uptake
This program comes with ABSOLUTELY NO WARRANTY. This is free software, and
you are welcome to redistribute it under GNU General Public License.