simmetab 0.2.0 © 2007,2011 by Turku PET Centre
Simulation of PET plasma time-radioactivity concentration curve (TAC)
of parent tracer and its metabolite from total arterial plasma (Ca) TAC
based on compartment model (1).
Usage: simmetab [Options] <Plasma file> <Parameter file> <Parent TAC file>
Options:
-metab=<Filename>
Write plasma metabolite TAC in specified file
-h or --help
Print this message and exit
-v, --version or --build
Print software build information and exit
--silent
Program works silently, printing only error and warning messages.
If the times in plasma file are in seconds, the units of rate constants
must be specified as 1/sec.
For accurate results, plasma data should have very frequent sampling.
Parameter file must contain (at least):
-Name of metabolite model
-Model parameter values
For example,
model := TPCMOD0009C
km := 0.8
k1m := 0.5
k2m := 0.4
k3m := 0.1
k4m := 0
Accepted metabolite models are:
-TPC metabolite model (2)
References:
1. Lammertsma AA, Hume SP, Bench CJ, Luthra SK, Osman S, Jones T. Measurement
of monoamine oxidase B activity using L-[11C]derenyl: Inclusion of
compartmental analysis of plasma metabolites and a new model not requiring
measurement of plasma metabolites. In: Quantification of Brain Function:
Tracer Kinetics and Image Analysis in Brain PET (Uemura K, Lassen NA,
Jones T, Kanno I, eds) Amsterdam, Excerpta Medica (pp) 313-318, 1993.
2. Oikonen V. New model for plasma metabolites.
http://www.turkupetcentre.net/reports/tpcmod0009_app_c.pdf
See also:
metabcor,
fit_ppf,
dft2svg
Keywords: DFT, input, metabolite correction, simulation
This program comes with ABSOLUTELY NO WARRANTY. This is free software, and
you are welcome to redistribute it under GNU General Public License.