Analysis of [18F]THK-5117 PET data

[18F]THK-5117 is a racemic tracer. Enantiomerically pure (S)-[18F]THK-5117 can be used instead of the racemic mixture if absolute quantification is required, because any differences in metabolism and kinetics between the S- and R-enantiomers would complicate the analysis (Jonasson et al., 2016).

[18F]THK-5117 PET studies have shown good visual separation of healthy subjects and Alzheimer’s disease (AD) patients, with high uptake in brain areas known to have high tau protein content in AD, and different uptake pattern than when using β-amyloid tracer [11C]PIB (Okamura et al., 2014; Harada et al., 2015).

Glymphatic system is a waste clearance system in the CNS. de Leon et al. (2017) have measured the ventricular clearance of [18F]THK-5117, and shown that CSF clearance is impaired in AD patients.

Analysis

Harada et al. (2015) performed a 90-min PET scan, and calculated the uptake ratios of regions-of-interest and cerebellar cortex. Jonasson et al. (2016) computed BPND for (S)-[18F]THK-5117 using plasma-input Logan plot, reference-input Logan plot, and SRTM, with cerebellum gray matter as reference region; VOI-based analysis provided robust results with all methods for scan durations of 60 min, and reference-input Logan performed best in computation of parametric images.

In mice tau disease model studies cerebellum has been used as reference region for calculation of SUV ratio and Logan plot (Brendel et al., 2016).


See also:



References:

Harada R, Okamura N, Furumoto S, Furukawa K, Ishiki A, Tomita N, Hiraoka K, Watanuki S, Shidahara M, Miyake M, Ishikawa Y, Matsuda R, Inami A, Yoshikawa T, Tago T, Funaki Y, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y. [18F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer’s disease. Eur J Nucl Med Mol Imaging 2015; 42(7): 1052-1061.

Jonasson M, Wall A, Chiotis K, Saint-Aubert L, Wilking H, Sprycha M, Borg B, Thibblin A, Eriksson J, Sörensen J, Antoni G, Nordberg A, Lubberink M. Tracer kinetic analysis of (S)-18F-THK5117 as a PET tracer for assessing tau pathology. J Nucl Med. 2016; 57(4): 574-581. doi: 10.2967/jnumed.115.158519.

Lemoine L, Saint-Aubert L, Marutle A, Antoni G, Eriksson JP, Ghetti B, Okamura N, Nennesmo I, Gillberg PG, Nordberg A. Visualization of regional tau deposits using 3H-THK5117 in Alzheimer brain tissue. Acta Neuropathol Commun. 2015; 3:40.

Okamura N, Furumoto S, Harada R, Tago T, Yoshikawa T, Fodero-Tavoletti M, Mulligan RS, Villemagne VL, Akatsu H, Yamamoto T, Arai H, Iwata R, Yanai K, Kudo Y. Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease. J Nucl Med. 2013; 54(8): 1420-1427.

Okamura N, Harada R, Furumoto S, Furukawa K, Ishiki A, Tomita N, Tashiro M, Iwata R, Yanai K, Arai H, Kudo Y. Comparison of 18F-THK5117 and 11C-PIB PET images in patients with Alzheimer’s disease. Alzheimer’s Dementia 2014; 10(4): P116.

Villemagne VL, Fodero-Tavoletti MT, Masters CL, Rowe CC. Tau imaging: early progress and future directions. Lancet Neurol. 2015; 14: 114-124.



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Created at: 2015-08-23
Updated at: 2017-12-31
Written by: Vesa Oikonen