b2t_h2o - tpcclib 0.7.7 © 2021 by Turku PET Centre
Simulation of PET tissue time-radioactivity concentration curve (TTAC)
in [O-15]H2O PET studies from decay corrected arterial blood TAC based on
the one-tissue compartment model.
Usage: b2t_h2o [options] bloodfile f p E Vb fA simfile
Perfusion (f) must be given in units mL/(min*100 mL), partition coefficient
(p) in units mL/mL, and vascular volume (Vb) and the arterial fraction of it
(fA) as percentages.
By default, blood flow (perfusion) and tissue concentratios are
assumed to represented per PET volume (including vascular volume).
Extraction coefficient, E=1-exp(-PS/f), can usually be set to 1.0.
Blood sample times must be in seconds, unless specified in the file.
For accurate results, blood input TAC should be noiseless and have very
short sampling intervals. Simulated curves can thereafter be interpolated
to represent PET frames using program fr4sim.
-sub | -nosub
TACs of sub-compartments are written (-sub)
or not written (-nosub, default) into the output file.
Simulated TACs are added to an existing tissue data file.
By default, existing file is overwritten.
Blood flow (perfusion) is assumed to be given per perfusable tissue
volume excluding vascular volume. TAC will still be simulated per
regional PET volume including vascular volume.
Enter a name (1-6 chars without spaces) for the simulated TAC
Save the simulated venous blood TAC
Display usage information on standard output and exit.
Display version and compile information on standard output and exit.
-d[n], --debug[=n], --verbose[=n]
Set the level (n) of debugging messages and listings.
Suppress displaying normal results on standard output.
Suppress displaying anything except errors.
Simulated TACs are written in ASCII format with columns:
1) Sample time (s)
2) Total tissue activity concentration (Cpet)
3) Activity concentration in tissue, (1-Vb)*Ct (optional)
4) Arterial contribution to tissue activity, Vb*fA*Cab (optional)
5) Venous contribution to tissue activity, Vb*(1-fA)*Cvb (optional)
See also: fit_h2o, sim_mbf, sim_3tcm, avgbolus, tacadd, simframe, tacunit
Keywords: TAC, simulation, modelling, perfusion, radiowater