sim_mbf - tpcclib 0.7.4 © 2019 by Turku PET Centre

Simulation of radiowater PET time-radioactivity concentration curves (TACs)
for myocardial muscle and LV cavity based on MBF model by Iida et al (1, 2)
as represented in ref 3.
 
Usage: sim_mbf [options] bloodfile MBF PTF Va Beta simfile
 
Options:
 -pH2O=<Partition coefficient for water>
     Enter the partition coefficient of water; 0.9464 by default.
 -sub | -nosub
     TAC of perfusbale tissue (Ct) is written (-sub)
     or not written (-nosub, default) into the simfile.
 -h, --help
     Display usage information on standard output and exit.
 -v, --version
     Display version and compile information on standard output and exit.
 -d[n], --debug[=n], --verbose[=n]
     Set the level (n) of debugging messages and listings.
 -q, --quiet
     Suppress displaying normal results on standard output.
 -s, --silent
     Suppress displaying anything except errors.
 
MBF must be given in units mL/(mL*min), and PTF and Va as fractions.
TACs of regional muscle, LV cavity, and optionally perfusable tissue are 
written in the given simfile, overwriting any previous contents.
 
For accurate results, blood input TAC should be noiseless and have very
short sampling intervals. Simulated curves can thereafter
be interpolated to represent PET frames using program simframe.
 
Example:
   sim_mbf s3456ab.bld 1.24 0.6 0.3 0.8 s3456sim.tac
 
References:
1. Iida H, Rhodes CG, de Silva R, Yamamoto Y, Araujo LI, Maseri A, Jones T.
   Myocardial tissue fraction - correction for partial volume effects and
   measure of tissue viability. J Nucl Med 1991; 32:2169-2175.
2. Iida H, Rhodes CG, de Silva R, Araujo LI, Bloomfield P, Lammertsma AA,
   Jones T. Use of the left ventricular time-activity curve as a noninvasive
   input function in dynamic oxygen-15-water positron emission tomography.
   J Nucl Med 1992; 33:1669-1677.
3. Oikonen V. Model equations for myocardial perfusion studies with [15O]H2O
   PET. http://www.turkupetcentre.net/reports/tpcmod0005.pdf
 
See also: fitmbf, b2t_h2o, sim_3tcm, tacadd, simframe, simimyoc
 
Keywords: simulation, myocardium, perfusion, radiowater