bfmsrtm - tpcclib 0.7.8 © 2022 by Turku PET Centre

Estimate the binding potential (BPnd) from simplified reference tissue
model (SRTM) (Lammertsma & Hume, 1996). The model is solved using
the basis function method (BFM; Gunn et al., 1997).
 
Radioactivity concentration in region(s)-of-interest is given in TTAC file;
data must be corrected for physical decay.
Radioactivity concentration in reference region (RTAC) is given in separate
file, or as name or number of the reference region inside the TTAC file.
Sample times must be in minutes in all data files, unless specified inside
the files. TTAC file should include weights.
 
Usage: bfmsrtm [options] TTAC RTAC results
 
Options:
 -i=<isotope>
     To apply BFM to non-decay-corrected data, as proposed in the original
     method publication, enter the isotope with this option, using codes
     C-11, F-18, Ga-68, Cu-64, ...
 -t3min=<value (1/min)>
     Set minimum value for theta3; it must be >= k2min/(1+BPmax)+lambda;
     it has to be > lambda. Default is lambda+0.001 min-1.
     Lambda for F-18 is 0.0063 and for C-11 0.034;
     If isotope is not given, then lambda=0.
 -t3max=<value (1/min)>
     Set maximum value for theta3; it must be <= k2max+lambda.
     Default is 0.60 min-1.
 -nr=<value>
     Set number of basis functions; default is 5000.
 -end=<Fit end time (min)>
     Use data from 0 to end time; by default, model is fitted to all frames.
 -DVR
     Instead of BPnd, program saves the DVR (=BPnd+1) values.
 -w1
     All weights are set to 1.0 (no weighting); by default, weights in
     data file are used, if available.
 -wf
     Weight by sampling interval.
 -svg=<Filename>
     Plots of original and fitted TTACs are written in specified file in
     SVG format.
 -fit=<Filename>
     Fitted regional TTACs are written in specified file.
 -bf=<filename>
     Basis functions are written in specified DFT file.
 -h, --help
     Display usage information on standard output and exit.
 -v, --version
     Display version and compile information on standard output and exit.
 -d[n], --debug[=n], --verbose[=n]
     Set the level (n) of debugging messages and listings.
 -q, --quiet
     Suppress displaying normal results on standard output.
 -s, --silent
     Suppress displaying anything except errors.
 
Example:
     bfmsrtm a4567.tac cer C-11 a4567bp.res
 
References:
1. Lammertsma AA, Hume SP. Simplified reference tissue model for PET
   receptor studies. NeuroImage 1996;4:153-158.
2. Gunn RN, Lammertsma AA, Hume SP, Cunningham VJ. Parametric imaging of
   ligand-receptor binding in PET using a simplified reference region
   model. NeuroImage 1997;6:279-287.
 
See also: tacweigh, tacdecay, logan, imgbfbp, fit_srtm, lhsrtm, fitk2
 
Keywords: TAC, modelling, binding potential, SRTM, reference input