bfmsrtm - tpcclib 0.8.0 © 2023 by Turku PET Centre
Estimate the binding potential (BPnd) from simplified reference tissue
model (SRTM) (Lammertsma & Hume, 1996). The model is solved using
the basis function method (BFM; Gunn et al., 1997).
Radioactivity concentration in region(s)-of-interest is given in TTAC file;
data must be corrected for physical decay.
Radioactivity concentration in reference region (RTAC) is given in separate
file, or as name or number of the reference region inside the TTAC file.
Sample times must be in minutes in all data files, unless specified inside
the files. TTAC file should include weights.
Usage: bfmsrtm [options] TTAC RTAC results
To apply BFM to non-decay-corrected data, as proposed in the original
method publication, enter the isotope with this option, using codes
C-11, F-18, Ga-68, Cu-64, ...
Set minimum value for theta3; it must be >= k2min/(1+BPmax)+lambda;
it has to be > lambda. Default is lambda+0.001 min-1.
Lambda for F-18 is 0.0063 and for C-11 0.034;
If isotope is not given, then lambda=0.
Set maximum value for theta3; it must be <= k2max+lambda.
Default is 0.60 min-1.
Set number of basis functions; default is 5000.
-end=<Fit end time (min)>
Use data from 0 to end time; by default, model is fitted to all frames.
Instead of BPnd, program saves the DVR (=BPnd+1) values.
All weights are set to 1.0 (no weighting); by default, weights in
data file are used, if available.
Weight by sampling interval.
Plots of original and fitted TTACs are written in specified file in
Fitted regional TTACs are written in specified file.
Basis functions are written in specified DFT file.
Display usage information on standard output and exit.
Display version and compile information on standard output and exit.
-d[n], --debug[=n], --verbose[=n]
Set the level (n) of debugging messages and listings.
Suppress displaying normal results on standard output.
Suppress displaying anything except errors.
bfmsrtm a4567.tac cer C-11 a4567bp.res
1. Lammertsma AA, Hume SP. Simplified reference tissue model for PET
receptor studies. NeuroImage 1996;4:153-158.
2. Gunn RN, Lammertsma AA, Hume SP, Cunningham VJ. Parametric imaging of
ligand-receptor binding in PET using a simplified reference region
model. NeuroImage 1997;6:279-287.
See also: tacweigh, tacdecay, logan, imgbfbp, fit_srtm, lhsrtm, fitk2
Keywords: TAC, modelling, binding potential, SRTM, reference input