fitk2 - tpcclib 0.7.9 © 2022 by Turku PET Centre
Non-linear fitting of one-tissue compartment model to plasma input, blood,
and tissue time-activity curves (PTAC, BTAC, and TTAC) to estimate
parameters K1, k2, and Vb. Sample times must be in minutes.
To fit only parameters K1 and Vb, assuming k2=0, create limit file (see options),
and set the lower and upper limit for K1/k2 to zero.
______ ______
| | K1 | |
| Ca | ---> | C1 |
|______| |______|
| k2
V
Usage: fitk2 [Options] ptacfile btacfile ttacfile endtime resultfile
Options:
-lim[=<filename>]
Specify the constraints for model parameters;
This file with default values can be created by giving this
option as the only command-line argument to this program.
Without filename the default values are printed on screen.
-SD[=<y|N>]
Standard deviations are calculated and saved in results (Y, default),
or not calculated (n).
Program runs a lot faster if SD and CL are not calculated.
-CL[=<y|N>]
95% Confidence limits are calculated and saved in results (y), or
not calculated (N, default).
-Vb=<Vb(%)>
Enter a fixed Vb; fitted by default.
-<BPnd|BPp|DVR>=<Reference region id or filename>
Optional reference region is used to calculate BPnd, BPp, or DVR;
BPnd=DVroi/DVref-1, BPp=DVroi-DVref, and DVR=DVroi/DVref
-fit=<Filename>
Fitted regional TACs are written in DFT format.
-svg=<Filename>
Fitted and measured TACs are plotted in specified SVG file.
-h, --help
Display usage information on standard output and exit.
-v, --version
Display version and compile information on standard output and exit.
-d[n], --debug[=n], --verbose[=n]
Set the level (n) of debugging messages and listings.
-q, --quiet
Suppress displaying normal results on standard output.
-s, --silent
Suppress displaying anything except errors.
Example 1: estimate K1, K1/k2 and Vb, with estimation of parameter SD
fitk2 -sd=y a919ap.bld a919ab.bld a919.tac 60 a919k2.res
Example 2: estimate K1 and DV (=K1/k2); Vb is constrained to 0%;
DVRs are calculated by dividing DVs by the DV of region 'cer'
fitk2 -Vb=0 -R=cer p25apc.bld none p25.tac 60 p25_k2.res
See also: logan, lhsoldv, fitk2di, fitk4, fit_h2o, p2t_v3c, tacweigh, taccbv
Keywords: TAC, modelling, distribution volume, reversible uptake, 1TCM