fitk2 - tpcclib 0.7.9 © 2022 by Turku PET Centre
Non-linear fitting of one-tissue compartment model to plasma input, blood,
and tissue time-activity curves (PTAC, BTAC, and TTAC) to estimate
parameters K1, k2, and Vb. Sample times must be in minutes.
To fit only parameters K1 and Vb, assuming k2=0, create limit file (see options),
and set the lower and upper limit for K1/k2 to zero.
| | K1 | |
| Ca | ---> | C1 |
Usage: fitk2 [Options] ptacfile btacfile ttacfile endtime resultfile
Specify the constraints for model parameters;
This file with default values can be created by giving this
option as the only command-line argument to this program.
Without filename the default values are printed on screen.
Standard deviations are calculated and saved in results (Y, default),
or not calculated (n).
Program runs a lot faster if SD and CL are not calculated.
95% Confidence limits are calculated and saved in results (y), or
not calculated (N, default).
Enter a fixed Vb; fitted by default.
-<BPnd|BPp|DVR>=<Reference region id or filename>
Optional reference region is used to calculate BPnd, BPp, or DVR;
BPnd=DVroi/DVref-1, BPp=DVroi-DVref, and DVR=DVroi/DVref
Fitted regional TACs are written in DFT format.
Fitted and measured TACs are plotted in specified SVG file.
Display usage information on standard output and exit.
Display version and compile information on standard output and exit.
-d[n], --debug[=n], --verbose[=n]
Set the level (n) of debugging messages and listings.
Suppress displaying normal results on standard output.
Suppress displaying anything except errors.
Example 1: estimate K1, K1/k2 and Vb, with estimation of parameter SD
fitk2 -sd=y a919ap.bld a919ab.bld a919.tac 60 a919k2.res
Example 2: estimate K1 and DV (=K1/k2); Vb is constrained to 0%;
DVRs are calculated by dividing DVs by the DV of region 'cer'
fitk2 -Vb=0 -R=cer p25apc.bld none p25.tac 60 p25_k2.res
See also: logan, lhsoldv, fitk2di, fitk4, fit_h2o, p2t_v3c, tacweigh, taccbv
Keywords: TAC, modelling, distribution volume, reversible uptake, 1TCM