lhsoldv 1.4.3 © 2002-2012 by Turku PET Centre

Estimates the distribution volume (DV) from compartmental model: Cp Ct ______ ___________________ | | K1 | k3 | 1-tissue CM | | --> | -------> | DV=K1/k2 | A | <-- | A <------- B | | | k2 | k4 | 2-tissue CM |______| |___________________| DV=(K1/k2)*(1+k3/k4) The model is transformed to general linear least squares functions [1], which are solved using Lawson-Hanson non-negative least squares (NNLS) algorithm [2]. DV is estimated directly without division [3,4,5]. Parameters: 1) Metabolite corrected plasma file 2) Tissue TAC file (*.dft) 3) Fit end time (duration) 4) Result file (existing file is overwritten) Options: -ref=<reference region name> When reference region is defined, DVR can be calculated as DVroi/DVref -h or --help Print this message and exit --version or --build Print software build information and exit --silent Program works silently, printing only error and warning messages --verbose Program prints more information about what it is doing. Options for selection of model: -0 Akaike weighted avg of 1- and 2-tissue compartment model results [6,7] -1 Force one-tissue compartment model for all regions -2 Force two-tissue compartment model for all regions -A Automatic selection of model for separate regions (default) Example: lhsoldv ua2918ap_pure.kbq ua2918.dft 90 ua2918dv.res References: 1. Blomqvist G. On the construction of functional maps in positron emission tomography. J Cereb Blood Flow Metab 1984;4:629-632. 2. Lawson CL & Hanson RJ. Solving least squares problems. Prentice-Hall, 1974. 3. Zhou Y, Brasic J, Endres CJ, Kuwabara H, Kimes A, Contoreggi C, Maini A, Ernst M, Wong DF. Binding potential image based statistical mapping for detection of dopamine release by [11C]raclopride dynamic PET. NeuroImage 2002;16(3):S91. 4. Zhou Y, Brasic JR, Ye W, Dogan AS, Hilton J, Singer HS, Wong DF. Quantification of cerebral serotonin binding in normal controls and subjects with Tourette's syndrome using [11C]MDL 100,907 and (+)[11C]McN 5652 dynamic PET with parametric imaging approach. NeuroImage 2004;22(Suppl 2):T98. 5. Hagelberg N, Aalto S, Kajander J, Oikonen V, Hinkka S, NĂ¥gren K, Hietala J, Scheinin H. Alfentanil increases cortical dopamine D2/D3 receptor binding in healthy subjects. Pain 2004;109:86-93. 6. Turkheimer FE, Hinz R, Cunningham VJ. On the undecidability among kinetic models: from model selection to model averaging. J Cereb Blood Flow Metab 2003; 23: 490-498. 7. Sederholm K. Model averaging with Akaike weights. TPCMOD0016 2003-04-07. http://www.turkupetcentre.net/reports/tpcmod0016.pdf See also: dftcbv, dftweigh, tac2svg, logan, fitk2, fitk4, imglhdv, rescoll Keywords: DFT, modelling, distribution volume, Vt, NNLS This program comes with ABSOLUTELY NO WARRANTY. This is free software, and you are welcome to redistribute it under GNU General Public License.

CC-GNU GPL Valid XHTML 1.0! Valid CSS!

Last updated 2012-08-14 12:50:14