fitk3 - tpcclib 0.7.8 © 2022 by Turku PET Centre

Non-linear fitting of two-tissue compartment model to plasma input, blood,
and tissue time-activity curves (PTAC, BTAC, and TTAC) to estimate
parameters K1, k2, k3, and Vb. Sample times must be in minutes.
 
    ______       ___________________           
   |      |  K1 |        k3         |          
   |      | --> |      ------->     |          
   |  Ca  | <-- |   C1 <------- C2  |          
   |      |  k2 |        k4=0       |          
   |______|     |___________________|          
 
Usage: fitk3 [Options] ptacfile btacfile ttacfile endtime resultfile
 
Options:
 -lim[=<filename>]
     Specify the constraints for model parameters;
     This file with default values can be created by giving this
     option as the only command-line argument to this program.
     Without filename the default values are printed on screen.
 -SD[=<y|N>]
     Standard deviations are calculated and saved in results (y),
     or not calculated (N, default).
     Program runs a lot faster if SD and CL are not calculated.
 -CL[=<y|N>]
     95% Confidence limits are calculated and saved in results (y), or
     not calculated (N, default).
 -Vb=<Vb(%)>
     Enter a fixed Vb; fitted by default.
 -r=<Reference region id or filename>
     Optional reference region is used to constrain K1/k2 in other regions;
     Also k3 is fitted to reference region data, thus any large region
     (for example cortex) can be used here.
 -fit=<Filename>
     Fitted regional TACs are written in DFT format.
 -svg=<Filename>
     Fitted and measured TACs are plotted in specified SVG file.
 -h, --help
     Display usage information on standard output and exit.
 -v, --version
     Display version and compile information on standard output and exit.
 -d[n], --debug[=n], --verbose[=n]
     Set the level (n) of debugging messages and listings.
 -q, --quiet
     Suppress displaying normal results on standard output.
 -s, --silent
     Suppress displaying anything except errors.
 
Example 1: estimate K1, K1/k2, k3 and Vb
     fitk3 ua919ap.bld ua919ab.bld ua919.tac 60 ua919k3.res
 
Example 2: estimate K1 and k3; Vb is constrained to 4.5% and K1/k2 is
constrained to K1/k2 estimated from region 'occip'
     fitk3 -Vb=4.5 -r=occip ua919ap.bld ua919ab.bld ua919.tac 60 ua919.res
 
See also: patlak, lhsol, p2t_v3c, tacweigh, taccbv, rescoll
 
Keywords: TAC, modelling, irreversible uptake, k3, Ki, 2TCM