fitk4di - tpcclib 0.8.1 © 2025 by Turku PET Centre

Non-linear fitting of dual input compartment model, with one tissue
compartment for each input (parent tracer and its labelled metabolite):
 
  _____   K1p   ______   k3p   ______  
 | Cap | ----> | Ct1p | ----> | Ct2p | 
 |_____| <---- |______| <---- |______| 
          k2p            k4p           
                                       
  _____   K1m   _____                  
 | Cam | ----> | Ctm |                 
 |_____| <---- |_____|                 
          k2m                          
 
Note that the model may be too complex to provide reliable parameter
estimates in most practical use cases.
 
Usage: fitk4di [Options] ptacfile mtacfile btacfile ttacfile endtime resultfile
 
Options:
 -lim[=<filename>]
     Specify the constraints for model parameters;
     This file with default values can be created by giving this
     option as the only command-line argument to this program.
     Without filename the default values are printed on screen.
 -SD=<y|N>
     Standard deviations are calculated and saved in results (y),
     or not calculated (N, default).
     Program runs a lot faster if SD and CL are not calculated.
 -CL=<y|N>
     95% Confidence limits are calculated and saved in results (y), or
     not calculated (N, default).
 -Vb=<Vb(%)>
     Enter a fixed Vb; fitted by default.
     If Vb (vascular blood volume) is pre-corrected or to be ignored, set
     it to 0; btacfile can be set to 'none'.
 -mc=<Filename>
     Fit-based metabolite corrected regional TACs are written in the file.
 -fit=<Filename>
     Fitted regional TACs are written in the file.
 -svg=<Filename>
     Fitted and measured TACs are plotted in specified SVG file.
 -h, --help
     Display usage information on standard output and exit.
 -v, --version
     Display version and compile information on standard output and exit.
 -d[n], --debug[=n], --verbose[=n]
     Set the level (n) of debugging messages and listings.
 -q, --quiet
     Suppress displaying normal results on standard output.
 -s, --silent
     Suppress displaying anything except errors.
 
Sample times must be in minutes.
 
Example: fitting with default settings
     fitk4di ia919apc.kbq ia919apm.kbq ia919ab.kbq ia919.dft 60 a919k4di.res
 
See also: fitk2di, fitk2, fitk4, sim_3tcm, tacweigh, taccbv
 
Keywords: TAC, modelling, distribution volume, dual-input