paucinf - tpcclib 0.7.3 © 2019 by Turku PET Centre

Estimates the half-life (t1/2) and elimination rate constant (kEL) of
a PET tracer in plasma, and the AUC of plasma time-activity curve (PTAC)
from 0 to infinite time. AUC can be used e.g. to estimate the total
clearance (ClT) of PET tracer after a single intravenous dose:
 
          Dose     
   Cl = --------   
     T  AUC        
           0-Inf   
 
The natural logarithm of tracer concentration is plotted against time
from bolus infusion. The plot becomes linear in the end phase, as the
tracer is eliminated according to the laws of first-order reaction
kinetics. The slope of the linear part of the plot equals -kEL.
 
Usage: paucinf [Options] ptacfile [resultfile]
 
Options:
 -end=<sample time>
     Use data from 0 to given time in the line fit; by default
     search for the best line fit extends to the last PTAC sample.
 -start=<sample time>
     Use data from given time to end in the line fit; by default,
     the search for the best line fit extends to the first sample.
 -winnonlin
     Best line fit is searched using algorithm that gives similar results
     to WinNonlin with the same simple model.
 -minnr=<sample number>
     Enter the minimum number of samples to use in the fit; by default 3.
 -svg=<Filename>
     Plots of log transformed TACs and fitted lines are written in specified
     SVG file.
 -h, --help
     Display usage information on standard output and exit.
 -v, --version
     Display version and compile information on standard output and exit.
 -d[n], --debug[=n], --verbose[=n]
     Set the level (n) of debugging messages and listings.
 -q, --quiet
     Suppress displaying normal results on standard output.
 -s, --silent
     Suppress displaying anything except errors.
 
Plasmafile must contain a time column, and one or more concentration columns
separated by space(s) or tabulator(s). The result is printed on screen.
 
See also: extrapol, interpol, fit_exp, fit2dat
 
Keywords: input, modelling, pharmacokinetics, clearance, elimination rate