paucinf - tpcclib 0.7.8 © 2022 by Turku PET Centre
Estimates the half-life (t1/2) and elimination rate constant (kEL) of
a PET tracer in plasma, and the AUC of plasma time-activity curve (PTAC)
from 0 to infinite time. AUC can be used e.g. to estimate the total
clearance (ClT) of PET tracer after a single intravenous dose:
CL = --------
The natural logarithm of tracer concentration is plotted against time
from bolus infusion. The plot becomes linear in the end phase, as the
tracer is eliminated according to the laws of first-order reaction
kinetics. The slope of the linear part of the plot equals -kEL.
Usage: paucinf [Options] ptacfile [resultfile]
Use data from 0 to given time in the line fit; by default
search for the best line fit extends to the last PTAC sample.
Use data from given time to end in the line fit; by default,
the search for the best line fit extends to the first sample.
Best line fit is searched using algorithm that gives similar results
to WinNonlin with the same simple model.
Enter the minimum number of samples to use in the fit; by default 3.
Plots of log transformed TACs and fitted lines are written in specified
Display usage information on standard output and exit.
Display version and compile information on standard output and exit.
-d[n], --debug[=n], --verbose[=n]
Set the level (n) of debugging messages and listings.
Suppress displaying normal results on standard output.
Suppress displaying anything except errors.
Plasmafile must contain a time column, and one or more concentration columns
separated by space(s) or tabulator(s). The result is printed on screen.
See also: extrapol, interpol, fit_exp, fit_dexp, fit2dat, fit2auc
Keywords: input, modelling, pharmacokinetics, clearance, elimination rate