Estimates the half-life (t1/2) and elimination rate constant (kEL) of a PET tracer in plasma, and the AUC of plasma time-activity curve (PTAC) from 0 to infinite time. AUC can be used e.g. to estimate the total clearance (ClT) of PET tracer after a single intravenous dose: Dose CL = -------- T AUC 0-Inf The natural logarithm of tracer concentration is plotted against time from bolus infusion. The plot becomes linear in the end phase, as the tracer is eliminated according to the laws of first-order reaction kinetics. The slope of the linear part of the plot equals -kEL. Usage: paucinf [Options] ptacfile [resultfile] Options: -end=<sample time> Use data from 0 to given time in the line fit; by default search for the best line fit extends to the last PTAC sample. -start=<sample time> Use data from given time to end in the line fit; by default, the search for the best line fit extends to the first sample. -winnonlin Best line fit is searched using algorithm that gives similar results to WinNonlin with the same simple model. -minnr=<sample number> Enter the minimum number of samples to use in the fit; by default 3. -svg=<Filename> Plots of log transformed TACs and fitted lines are written in specified SVG file. -h, --help Display usage information on standard output and exit. -v, --version Display version and compile information on standard output and exit. -d[n], --debug[=n], --verbose[=n] Set the level (n) of debugging messages and listings. -q, --quiet Suppress displaying normal results on standard output. -s, --silent Suppress displaying anything except errors. Plasmafile must contain a time column, and one or more concentration columns separated by space(s) or tabulator(s). The result is printed on screen. See also: extrapol, interpol, fit_exp, fit_dexp, fit2dat, fit2auc Keywords: input, modelling, pharmacokinetics, clearance, elimination rate

This program comes with ABSOLUTELY NO WARRANTY. This is free software, and you are welcome

to redistribute it under GNU General Public License.

Source codes are available in https://gitlab.utu.fi/vesoik/tpcclib.git.