regfur - tpcclib 0.7.2 © 2019 by Turku PET Centre

Calculates Fractional Uptake Rate (FUR) or FUR-based Metabolic Rate (MR)
from regional PET TTACs. Information on FUR in:
http://www.turkupetcentre.net/petanalysis/model_fur.html
 
Usage: regfur [Options] inputfile ttacfile starttime endtime resultfile
 
FUR calculation start and stop time must be entered in minutes;
set both to zero to use the whole time range from TTAC data.
 
Options:
 -Ca=<value>
     Concentration of native substrate in arterial plasma (mM),
     for example plasma glucose in [18F]FDG studies.
     With this option the metabolic rate (umol/(min*100 g)) is calculated.
 -LC=<value>
     Lumped Constant in MR calculation; default is 1.0.
 -density=<value>
     Tissue density in MR calculation; default is 1.0 g/ml.
 -curve=<filename>
     FUR as a function of time is written in specified file; this can be
     used to study the time-dependence of FUR estimates.
 -it=<Time (min)>
     Input AUC is normally calculated from 0 to the middle time of FUR
     calculation time; in special cases this option can be used to
     calculate it from 0 to the specified time instead.
 -deriv[ative]
     Tentative option for calculating FUR as ratio of tissue derivative and
     plasma. This does not affect the FUR curve made with option -curve.
 -h, --help
     Display usage information on standard output and exit.
 -v, --version
     Display version and compile information on standard output and exit.
 -d[n], --debug[=n], --verbose[=n]
     Set the level (n) of debugging messages and listings.
 -q, --quiet
     Suppress displaying normal results on standard output.
 -s, --silent
     Suppress displaying anything except errors.
 
Example 1. Calculation of FUR from dynamic PET data from 45 to 60 min:
     regfur ua2918ap.kbq ua2918dy1.dft 45 60 ua2918fur.res
 
Example 2. Calculation of glucose uptake, when tissue density is 1.04,
plasma glucose concentration is 5.2 mM, lumped constant is 0.52, from
a static (one frame) scan:
     regfur -Ca=5.2 -LC=0.52 -d=1.04 a864ap.kbq a864dy1.dft 0 0 a864mrglu.res
 
FUR and MR results are saved in result file format by default, but if
filename extension is set to .dft, .csv, .dat, or .html, results are saved
in those formats.
 
The unit of FUR is (mL plasma)/(min*(mL tissue)) by default, and
umol/(min*100 g) if metabolic rate is calculated.
 
See also: patlak, dftinteg, taccalc, tactime, dftsuv, rescoll, imgfur
 
Keywords: TAC, modelling, FUR, retention index, irreversible uptake