regfur - tpcclib 0.8.0 © 2023 by Turku PET Centre
Calculates Fractional Uptake Rate (FUR) or FUR-based Metabolic Rate (MR)
from regional PET TTACs. Information on FUR in:
Usage: regfur [Options] inputfile ttacfile starttime endtime resultfile
FUR calculation start and stop time must be entered in minutes;
set both to zero to use the whole time range from TTAC data.
Concentration of native substrate in arterial plasma (mM),
for example plasma glucose in [18F]FDG studies.
With this option the metabolic rate (umol/(min*100 g)) is calculated.
Lumped Constant in MR calculation; default is 1.0.
Tissue density in MR calculation; default is 1.0 g/ml.
FUR as a function of time is written in specified file; this can be
used to study the time-dependence of FUR estimates.
Input AUC is normally calculated from 0 to the middle time of FUR
calculation time; in special cases this option can be used to
calculate it from 0 to the specified time instead.
Tentative option for calculating FUR as ratio of tissue derivative and
plasma. This does not affect the FUR curve made with option -curve.
Display usage information on standard output and exit.
Display version and compile information on standard output and exit.
-d[n], --debug[=n], --verbose[=n]
Set the level (n) of debugging messages and listings.
Suppress displaying normal results on standard output.
Suppress displaying anything except errors.
Example 1. Calculation of FUR from dynamic PET data from 45 to 60 min:
regfur ua2918ap.kbq ua2918dy1.dft 45 60 ua2918fur.res
Example 2. Calculation of glucose uptake, when tissue density is 1.04,
plasma glucose concentration is 5.2 mM, lumped constant is 0.52, from
a static (one frame) scan:
regfur -Ca=5.2 -LC=0.52 -d=1.04 a864ap.kbq a864dy1.dft 0 0 a864mrglu.res
FUR and MR results are saved in result file format by default, but if
filename extension is set to .dft, .csv, .dat, or .html, results are saved
in those formats.
The unit of FUR is (mL plasma)/(min*(mL tissue)) by default, and
umol/(min*100 g) if metabolic rate is calculated.
See also: patlak, dftinteg, taccalc, tactime, dftsuv, rescoll, imgfur
Keywords: TAC, modelling, FUR, retention index, irreversible uptake