sim_wliv - tpcclib 0.7.4 © 2019 by Turku PET Centre
Simulation of PET tissue time-radioactivity concentration curves (TACs)
from arterial blood (Ca) TACs, based on compartmental model for radiowater
kinetics in the liver. Liver has two inputs, hepatic artery and portal vein.
Portal vein input is simulated by assuming that GI tract can be modelled
with time delay and dispersion of the arterial input function.
Model has two parameters for the perfusion, represented by K1a and K1p for
the arterial and portal blood flow, respectively, and a single parameter p
for the partition coefficient of water (p).
There are two delay times, LdT, which is the delay between the Ca and liver,
and PdT, which is the additional delay in the portal vein blood.
Dispersion the the GI tract is accounted for by rate constant kGI.
The volume fraction of arterial blood (Vb) is assumed to contain arterial
and portal blood in proportion to their contribution to the total blood flow.
Usage: sim_wliv [options] parfile [bloodfile simfile]
Display usage information on standard output and exit.
Display version and compile information on standard output and exit.
-d[n], --debug[=n], --verbose[=n]
Set the level (n) of debugging messages and listings.
Suppress displaying normal results on standard output.
Suppress displaying anything except errors.
To create a template parameter file, do not enter names for arterial input
and simulated TACs.
If parameter file does not contain units, then per min and per mL units
are assumed for K1a, K1p, p, kGI, and Vb, and seconds for deley times.
For accurate results, blood TAC should have very short sampling intervals.
See also: sim_h2o, fit_wliv, liverpv, simdisp, fit_h2o, tacadd, simframe
Keywords: liver, simulation, compartmental model, perfusion, radiowater